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Cochrane for Clinicians

Proton Pump Inhibitors to Prevent NSAID-Induced Ulcers and Dyspepsia

Tracy Johns, PharmD, MSMS, BCACP,
Elizabeth Lawrence, MD, FAAFP, DABOM,
USF College of Medicine, Tampa, Florida

American Family Physician. 2025;112(6):607-608.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

  1. 1.Garegnani L, Oltra G, Burgos MA, et al. Proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug–induced ulcers and dyspepsia. Cochrane Database Syst Rev. 2025(5):CD014585.
  2. 2.Wongrakpanich S, Wongrakpanich A, Melhado K, et al. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging Dis. 2018;9(1):143-150.
  3. 3.McConaghy JR, Decker A, Nair S. Peptic ulcer disease and H. pylori infection: common questions and answers. Am Fam Physician. 2023;107(2):165-172.
  4. 4.Lanza FL, Chan FKL, Quigley EMM, et al. Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol. 2009;104(3):728-738.

These are summaries of reviews from the Cochrane Library.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at https://www.aafp.org/afp/cochrane.

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