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Point-of-Care Guides

Assessing the Risk of Heart Failure With Preserved Ejection Fraction in Individuals With Exertional Dyspnea

Aaron Saguil, MD, MPH
Petra Townsend, MD
Mark H. Ebell, MD, MS

American Family Physician. 2025;112(6):686-687.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

AARON SAGUIL, MD, MPH, FAAFP, and PETRA TOWNSEND, MD, FAAFP, University of Florida, Gainesville

MARK EBELL, MD, MS, Michigan State University, East Lansing

Address correspondence to Aaron Saguil, MD, MPH, FAAFP, at a.saguil@ufl.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79(17):e263-e421.
  2. 2.Karakasis P, Pamporis K, Stachteas P, et al. Efficacy and safety of sodium-glucose cotransporter-2 inhibitors in heart failure with mildly reduced or preserved ejection fraction: an overview of 36 systematic reviews. Heart Fail Rev. 2023;28(5):1033-1051.
  3. 3.Packer M, Zile MR, Kramer CM, et al.; SUMMIT Trial Study Group. Tirzepatide for heart failure with preserved ejection fraction and obesity. N Engl J Med. 2025;392(5):427-437.
  4. 4.Reddy YNV, Carter RE, Obokata M, et al. A simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction. Circulation. 2018;138(9):861-870.
  5. 5.Pieske B, Tschöpe C, de Boer RA, et al. How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J. 2019;40(40):3297-3317.
  6. 6.Barandiarán Aizpurua A, Sanders-van Wijk S, Brunner-La Rocca HP, et al. Validation of the HFA-PEFF score for the diagnosis of heart failure with preserved ejection fraction. Eur J Heart Fail. 2020;22(3):413-421.
  7. 7.Reddy YNV, Carter RE, Sundaram V, et al. An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score. Nat Med. 2024;30(8):2258-2264.

This guide is one in a series that offers evidence-based tools to assist family physicians in improving their decision-making at the point of care.

This series is coordinated by Mark H. Ebell, MD, MS, deputy editor for evidence-based medicine.

A collection of Point-of-Care Guides published in AFP is available at https://www.aafp.org/afp/poc.

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