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Cochrane for Clinicians

RSV Vaccination During Pregnancy Improves Infant Outcomes

Prakhya Bhatnagar, MD,
Elizabeth Tennant, MD,
TriStar Southern Hills Family Medicine Residency Program, Nashville, Tennessee

American Family Physician. 2025;112(3):257-258.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

  1. 1.Phijffer EW, de Bruin O, Ahmadizar F, et al. Respiratory syncytial virus vaccination during pregnancy for improving infant outcomes. Cochrane Database Syst Rev. 2024(5):CD015134.
  2. 2.Centers for Disease Control and Prevention. Surveillance of RSV. July 8, 2025. Accessed July 26,2025. https://www.cdc.gov/rsv/php/surveillance/index.html#:~:text=RSV%20burden%20estimates,adults%2060%20years%20and%20older
  3. 3.Li Y, Wang X, Blau DM, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet. 2022;399(10340):2047-2064.
  4. 4.Abu Raya B, Edwards KM, Scheifele DW, et al. Pertussis and influenza immunisation during pregnancy: a landscape review. Lancet Infect Dis. 2017;17(7):e209-e222.
  5. 5.Faucette AN, Unger BL, Gonik B, et al. Maternal vaccination: moving the science forward. Hum Reprod Update. 2015;21(1):119-135.
  6. 6.Chu HY, Tielsch J, Katz J, et al. Transplacental transfer of maternal respiratory syncytial virus (RSV) antibody and protection against RSV disease in infants in rural Nepal. J Clin Virol. 2017;95:90-95.
  7. 7.Fleming-Dutra KE, Jones JM, Roper LE, et al. Use of the Pfizer respiratory syncytial virus vaccine during pregnancy for the prevention of respiratory syncytial virus–associated lower respiratory tract disease in infants: recommendations of the Advisory Committee on Immunization Practices—United States, 2023. MMWR Morb Mortal Wkly Rep. 2023;72(41):1115-1122.
  8. 8.American College of Obstetricians and Gynecologists. Maternal respiratory syncytial virus vaccination. Updated March 17, 2025. Accessed July 26,2025. https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2023/09/maternal-respiratory-syncytial-virus-vaccination
  9. 9.Respiratory syncytial virus. In: Kimberlin DW, Banerjee R, Barnett ED, et al., eds. Red Book 2024–2027 Report of the Committee on Infectious Diseases 33rd ed. American Academy of Pediatrics; 2024: 713–721.
  10. 10.Maternal Immunization Task Force. Obstetric care professionals recommend RSV vaccine for pregnant individuals. October 2023. Accessed March 7, 2025. https://www.acog.org/-/media/project/acog/acogorg/files/pdfs/news/rsv-joint-statement-2023.pdf?rev=a2b7b480096c4659bd18af4baf837d10&hash=A966813C2C94FB3C11CBAA6012A4943A

These are summaries of reviews from the Cochrane Library.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at https://www.aafp.org/afp/cochrane.

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