FPIN's Clinical Inquiries
From the Family Practice Inquiries Network

Oral Prostaglandins for Labor Induction

Samantha Pinedo, DO
David Lin, DO
Kris Sherwood, MD
Jon O. Neher, MD

American Family Physician. 2025;112(3):328-329.

Author disclosure: No relevant financial relationships.

SAMANTHA PINEDO, DO; DAVID LIN, DO; KRIS SHERWOOD, MD; and JON O. NEHER, MD, Valley Family Medicine, Renton, Washington

Address correspondence to Samantha Pinedo, DO, at samantha_pinedo@valleymed.org.

Author disclosure: No relevant financial relationships.

  1. 1.Alfirevic Z, Aflaifel N, Weeks A. Oral misoprostol for induction of labour. Cochrane Database Syst Rev. 2014(6):CD001338.
  2. 2.Padayachee L, Kale M, Mannerfeldt J, et al. Oral misoprostol for induction of labour in term PROM: a systematic review. J Obstet Gynaecol Can. 2020;42(12):1525-1531.e1.
  3. 3.Ahmed RHM, Sweed MSE, El-Bishry GA, et al. Oxytocin versus oral misoprostol for induction of labor in pregnant women with term prelabor rupture of membranes: a randomized clinical trial. Reprod Sci. 2023;30(12):3507-3514.
  4. 4.Bender WR, Mccoy JA, Levine LD. Oxytocin vs oral misoprostol for PROM induction in nulliparas with unfavorable cervix: a randomized trial. Am J Obstet Gynecol MFM. 2024;6(8):101414.
  5. 5.Prelabor rupture of membranes: ACOG practice bulletin, number 217. Obstet Gynecol. 2020;135(3):e80-e97.

Clinical Inquiries provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). Members of the network select questions based on their relevance to family medicine. Answers are drawn from an approved set of evidence-based resources and undergo peer review. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www.cebm.net).

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This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

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