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Diagnostic Tests

EpiSwitch Prostate Cancer Screening Test

Michael Partin, MD
Seth Martin, MD
Zakary Newberry, MD

American Family Physician. 2025;112(3):325-326.

Author disclosure: No relevant financial relationships.

MICHAEL PARTIN, MD, FAAFP; SETH MARTIN, MD; and ZAKARY NEWBERRY, MD, Penn State Health Milton S. Hershey Medical Center, Hershey

Address correspondence to Michael T. Partin, MD, FAAFP, at mpartin@pennstatehealth.psu.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Pinsky PF, Parnes HL, Andriole G. Mortality and complications after prostate biopsy in the Prostate, Lung, Colorectal and Ovarian Cancer Screening (PLCO) trial. BJU Int. 2014;113(2):254-259.
  2. 2.Fenton JJ, Weyrich MS, Durbin S, et al. Prostate-specific antigen-based screening for prostate cancer: evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2018;319(18):1914-1931.
  3. 3.McNaughton-Collins M, Fowler FJ, Caubet JF, et al. Psychological effects of a suspicious prostate cancer screening test followed by a benign biopsy result. Am J Med. 2004;117(10):719-725.
  4. 4.Fowler FJ, Barry MJ, Walker-Corkery B, et al. The impact of a suspicious prostate biopsy on patients' psychological, socio-behavioral, and medical care outcomes. J Gen Intern Med. 2006;21(7):715-721.
  5. 5.Sanda MG, Dunn RL, Michalski J, et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med. 2008;358(12):1250-1261.
  6. 6.Talcott JA, Rieker P, Clark JA, et al. Patient-reported symptoms after primary therapy for early prostate cancer: results of a prospective cohort study. J Clin Oncol. 1998;16(1):275-283.
  7. 7.US Preventive Services Task Force. Prostate cancer: screening. May 8, 2018. Accessed November 11, 2024. https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening
  8. 8.Pohlman GD. EpiSwitch® prostate screening (PSE) blood test. Grand Rounds in Urology September 2024. Accessed November 9, 2024. https://grandroundsinurology.com/episwitch-prostate-screening-pse-blood-test/
  9. 9.Oxford Biodynamics announces US launch of its 94% accurate EpiSwitch prostate screening blood test to men with prostate cancer risk. News release. Businesswire. September 26, 2023. Accessed November 9, 2024. https://www.businesswire.com/news/home/20230926908052/en/Oxford-Biodynamics-Announces-US-Launch-of-its-94-Accurate-EpiSwitch%C2%AE-Prostate-Screening-Blood-Test-to-Men-With-Prostate-Cancer-Risk
  10. 10.Pchejetski D, Hunter E, Dezfouli M, et al. Circulating chromosome conformation signatures significantly enhance PSA positive predicting value and overall accuracy for prostate cancer detection. Cancers (Basel). 2023;15(3):821.
  11. 11.Oxford BioDynamics. EpiSwitch® prostate cancer detection (PSE) test. Accessed November 9, 2024. https://www.94percent.com/
  12. 12.Centers for Medicare & Medicaid Services. 24CLABQ4. Accessed November 9, 2024. https://www.cms.gov/medicare/payment/fee-schedules/clinical-laboratory-fee-schedule-clfs/files/24clabq4
  13. 13.Centers for Medicare & Medicaid Services. List of CPT/HCPCS codes. Accessed November 9, 2024. https://www.cms.gov/license/ama?file=/files/zip/updated-list-codes-effective-january-1-2024-published-march-1-2024.zip

This series is coordinated by Natasha Pyzocha, DO, contributing editor.

A collection of Diagnostic Tests published in AFP is available at https://www.aafp.org/afp/diagnostic.

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