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FPIN's Clinical Inquiries
From the Family Practice Inquiries Network

Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis

Jason W. Deck, MD
Andrew Young, MD
Emrys Moreau, MFA, MLIS

American Family Physician. 2025;112(5):558-559.

Author disclosure: No relevant financial relationships.

JASON W. DECK, MD, and ANDREW YOUNG, MD, Department of Family and Community Medicine, University of Oklahoma School of Community Medicine, Tulsa

EMRYS MOREAU, MFA, MLIS, University of Oklahoma-Tulsa, Schusterman Library, Tulsa

Address correspondence to Jason W. Deck, MD, at Jason-Deck@ouhsc.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Berkani S, Courties A, Eymard F, et al. Time to total knee arthroplasty after intra-articular hyaluronic acid or platelet-rich plasma injections: a systematic literature review and meta-analysis. J Clin Med. 2022;11(14):3985.
  2. 2.Mordin M, Parrish W, Masaquel C, et al. Intra-articular hyaluronic acid for osteoarthritis of the knee in the United States: a systematic review of economic evaluations. Clin Med Insights Arthritis Musculoskelet Disord. 2021;14 : 11795441211047284.
  3. 3.Park JG, Sim J, Han SB. Association between intra-articular hyaluronic acid injections in delaying total knee arthroplasty and safety evaluation in primary knee osteoarthritis: analysis based on Health Insurance Review and Assessment Service (HIRA) claim database in Republic of Korea. BMC Musculoskelet Disord. 2024;25(1):706.

Clinical Inquiries provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). Members of the network select questions based on their relevance to family medicine. Answers are drawn from an approved set of evidence-based resources and undergo peer review. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www.cebm.net).

The complete database of evidence-based questions and answers is copyrighted by FPIN. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email questions@fpin.org.

Copyright © Family Physicians Inquiries Network. Used with permission.

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of FPIN’s Clinical Inquiries published in AFP is available at https://www.aafp.org/afp/fpin.

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