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STEPS
New Drug Reviews

Intranasal Epinephrine (Neffy) for Emergency Treatment of Type I Allergic Reactions

Jennifer Wolf, MD
Jessica Fournier, MD

American Family Physician. 2026;113(3):270-272.

Author disclosure: No relevant financial relationships.

JENNIFER WOLF, MD, and JESSICA FOURNIER, MD, Lowell Community Health Center, Lowell, Massachusetts

Address correspondence to Jennifer Wolf, MD, at jenniferwo@lchealth.org.

Author disclosure: No relevant financial relationships.

  1. 1.DailyMed. Neffy – epinephrine spray. Accessed December 16, 2025. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=758142-a905-401d-8961-05829f51023a
  2. 2.Casale TB, Ellis AK, Nowak-Wegrzyn A, et al. Pharmacokinetics/pharmacodynamics of epinephrine after single and repeat administration of Neffy, EpiPen, and manual intramuscular injection. J Allergy Clin Immunol. 2023;152(6):1587-1596.
  3. 3.Tanimoto S, Kaliner M, Lockey RF, et al. Pharmacokinetic and pharmacodynamic comparison of epinephrine, administered intranasally and intramuscularly: an integrated analysis. Ann Allergy Asthma Immunol. 2023;130(4):508-514.e1.
  4. 4.Chooniedass R, Temple B, Becker A. Epinephrine use for anaphylaxis: too seldom, too late: current practices and guidelines in health care. Ann Allergy Asthma Immunol. 2017;119(2):108-110.

STEPS new drug reviews cover Safety, Tolerability, Effectiveness, Price, and Simplicity. Each independent review is provided by authors who have no financial association with the drug manufacturer.

This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor.

A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps.

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