March 2026

Diagnosis of acute or chronic urticaria is usually based on history and physical examination findings. Preferred acute urticaria treatment includes second-generation H1 antihistamines; first-line treatment of chronic urticaria follows a stepped plan that includes second…

All adults should be screened at least once for hepatitis B using triple panel testing, and vaccination should be offered to all adults 19 to 59 years of age regardless of risk.

Chronic hepatitis B infection is diagnosed when hepatitis B surface antigen is present for at least 6 months. Therapy with oral nucleoside/nucleotide analogues can reduce the risk of cirrhosis, hepatocellular carcinoma, and liver-related mortality.

Multiple myeloma is a hematologic malignancy of plasma cells that affects approximately 36,000 people annually in the United States, with a median age at diagnosis of 69 years. Diagnosis involves laboratory tests, imaging, and bone marrow analysis. Treatment is determined by…

Croup is a common childhood respiratory illness causing a characteristic barking cough, hoarseness, and inspiratory stridor. It is treated with corticosteroids and nebulized epinephrine. Recurrent croup should prompt evaluation for an underlying anatomic abnormality or medical…

Meningitis is the inflammation of the meninges from viral, bacterial, fungal, noninfectious, or unknown causes. Viral pathogens are responsible for up to 60% of cases. Meningitis may cause neck stiffness, fever, headache, and altered mentation.

Preconception, antepartum, and postpartum care for patients who are obese.

Rapid changes in the drug supply, including additives and contaminants, can have profound clinical impacts. Since 2024, a new additive, medetomidine, has been implicated in overdose and complicated withdrawal in several major metropolitan areas.

Long-acting reversible contraceptives (LARCs), including intrauterine devices (IUDs) and etonogestrel single rod implants, are effective in preventing unintended pregnancy. In the post-Dobbs era, it is important for family physicians to expand access to LARCs because previous…

A color recommendation of yellow (unclear benefits) is assigned for the use of sustained-release naltrexone for opioid dependence because of significant limitations of the findings.

Visual estimation of blood loss is not very sensitive (22%-48%) but is very specific (97%-99%) when used to diagnose postpartum hemorrhage in patients who deliver vaginally in a hospital setting. In contrast, using a calibrated drape plus observations (eg, heart rate, blood…

Children aged 1 to 2 years who begin using toothpaste with higher fluoride concentrations (1,000 ppm or more vs less than 1,000 ppm) are at increased risk of developing dental fluorosis (mottling or discoloration) in permanent teeth.

Intranasal epinephrine is an alternative to current injectable forms of emergency epinephrine. It may be a functional tool for patients who are hesitant or resistant to using needles, but it is more expensive than current injectable options.

The USPSTF recommends screening for depression in the adult population, including pregnant and postpartum persons, as well as older adults. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for suicide risk…

This PPIP quiz is based on the recommendations of the USPSTF.

A collaboration between AFP and the Lown Institute promotes a vision of delivering health care that is based on the evidence, balanced in its approach, and focused on the patient.

POEMs

POEMs

POEMs

POEMs

A 62-year-old man presented with a slowly growing left abdominal mass.

An 11-year-old boy presented with a rash on his back, abdomen, arms, and legs.

Physicians should counsel adults treated with sodium-glucose cotransporter-2 inhibitors about an increased risk of genital infections.

The Q-Pad Test represents a novel, at-home method for measuring A1C, using menstrual blood. Although multiple small observational studies have shown close agreement with venous A1C values, limitations such as potential selection and observer bias, lack of independent validation…

In people 80 years and older taking a direct oral anticoagulant, who is at increased risk for major hemorrhage?

This guideline from the American Heart Association and American Red Cross provides guidance on administering first aid.

The Endocrine Society has updated its guidelines on the evidence for vitamin D supplementation and testing for disease prevention.

Reply: James J. Arnold, David Villaneuva, Melissa Jane Puntkatalee

Letters to the Editor

Incorrect CME Quiz answer. In the “Answers to This Issue's CME Quiz” box (February 2026, p. 201), the answer listed for Q7 was incorrect. The correct answer should have been listed as “B.” The online CME quiz has been corrected.

Incorrect algorithm information. “Newborn Respiratory Distress: Evaluation and Management” (January 2026, p. 37) included extraneous information in the “Follow neonatal resuscitation algorithm” section of Figure 1. The online version of the article has been corrected.

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