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Medicine by the Numbers

Sustained-Release Naltrexone for Opioid Dependence

Ross Stanton, MD, JD, MPH
Joshua Lujan, DO
Christina Valerio, MD, MPH

American Family Physician. 2026;113(3):217A-217B.

Author disclosure: No relevant financial relationships.

ROSS STANTON, MD, JD, MPH; JOSHUA LUJAN, DO; and CHRISTINA VALERIO, MD, MPH, Scott Air Force Base, Illinois

Address correspondence to Christina Valerio, MD, MPH, at christina.r.valerio.mil@health.mil.

Author disclosure: No relevant financial relationships.

  1. 1.Degenhardt L, Webb P, Colledge-Frisby S, et al. Epidemiology of injecting drug use, prevalence of injecting-related harm, and exposure to behavioural and enviornmental risks among people who inject drugs: a systematic review. Lancet Glob Health. 2023;11(5):e659-e672.
  2. 2.World Health Organization, Department for HIV, Tuberculosis, Hepatitis and Sexually Transmitted Infections. People who inject drugs. Accessed February 13, 2026. https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/populations/people-who-inject-drugs
  3. 3.Kornør H, Lobmaier PPK, Kunøe N. Sustained-release naltrexone for opioid dependence. Cochrane Database Syst Rev. 2025(5):CD006140.

Copyright ©2026 MD Aware, LLC (theNNT.com). Used with permission.

This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

A collection of Medicine by the Numbers published in AFP is available at https:// www.aafp.org/afp/mbtn.

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