FPIN's Clinical Inquiries
From the Family Practice Inquiries Network

SGLT-2 Inhibitors and Increased Risk of Urogenital Infections

Julia Swanson, MD
Kathleen Lucier, DO
Maikha Jean-Baptiste, MD
Jon O. Neher, MD

American Family Physician. 2026;113(3):281-282.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

JULIA SWANSON, MD; KATHLEEN LUCIER, DO; MAIKHA JEAN-BAPTISTE, MD; and JON O. NEHER, MD, Valley Family Medicine, Renton, Washington

Address correspondence to Jon O. Neher, MD, at jon_neher@valleymed.org.

Author disclosure: No relevant financial relationships.

  1. 1.Sridharan K, Sivaramakrishnan G. Genito-urinary infectious adverse events related to sodium glucose cotransporter-2 inhibitors: a network meta-analysis and meta-regression. Expert Rev Clin Pharmacol. 2024;17(5–6):515-524.
  2. 2.Bapir R, Bhatti KH, Eliwa A, et al. Risk of urogenital infections in non-diabetic patients treated with sodium glucose transporter 2 (SGLT2) inhibitors. Systematic review and meta-analysis. Arch Ital Urol Androl. 2023;95(2):11509.
  3. 3.Cahn A, Mosenzon O, Wiviott SD, et al. Efficacy and safety of dapagliflozin in the elderly: analysis from the DECLARE-TIMI 58 study. Diabetes Care. 2020;43(2):468-475.
  4. 4.Dave CV, Schneeweiss S, Patorno E. Association of sodium-glucose transporter 2 inhibitor treatment with risk of hospitalization with Fournier gangrene among men. JAMA Intern Med. 2019;179(11):1587-1590.

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