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Am Fam Physician. 2023;107(6):568

Author disclosure: No relevant financial relationships.

To the Editor: Dr. Patel and colleagues' article about peripheral edema discussed venous thromboembolism as a potential etiology for peripheral edema.1 In their discussion about the treatment of deep venous thrombosis, the authors suggest that compression stockings prevent the development of postthrombotic syndrome.1 To clarify, the Cochrane review concluded that compression stockings “may” reduce the occurrence of postthrombotic syndrome; however, the review stated that the evidence for that recommendation is of low quality.2 The 2020 American Society of Hematology guidelines for the management of venous thromboembolism recommended specifically against the routine use of compression stockings to prevent postthrombotic syndrome.3 Per the guideline, compression stockings “may help to reduce edema and pain associated with acute deep venous thrombosis in selected patients.”3

Editor's Note: This letter was sent to the authors of “Peripheral Edema: Evaluation and Management in Primary Care,” who declined to reply.

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This series is coordinated by Kenny Lin, MD, MPH, deputy editor.

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