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Am Fam Physician. 2024;109(4):310-311

Author disclosure: No relevant financial relationships.

Details for This Review

Study Population: 36 studies with 23,299 women in two main groups: early menopausal women (fewer than 5 years since amenorrhea or menopause) with or without menopausal symptoms and “unselected” postmenopausal women (last menstrual period more than 5 years earlier, regardless of menopausal symptoms)

Efficacy End Points: Primary: sexual-function composite score; secondary: domains of sexual function, including desire, arousal, lubrication, orgasm, satisfaction, and pain

Harm End Points: Not evaluated in this review

Slight improvement in sexual-function composite score for estrogen alone compared with placebo or no intervention (standardized mean difference = 0.50; 95% CI, 0.04 to 0.96) in women experiencing early postmenopause (< 5 years since amenorrhea) or experiencing other symptoms due to menopause
Slight improvement in sexual-function composite score for selective estrogen-receptor modulators compared with placebo or no intervention (mean difference = 2.24; 95% CI, 1.37 to 3.11) in unselected postmenopausal women
Not evaluated
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This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

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