Midodrine as a Treatment Option for Recurrent Vasovagal Syncope

Amy Pearcy; Gracie Rubideaux; Palvinder Garcha; Rob Meyer

Cognitive Rehabilitation for Patients With Dementia

Jul 2024

Bupropion for Depression in Adolescents

FPIN's Help Desk Answers

Midodrine as a Treatment Option for Recurrent Vasovagal Syncope

Amy Pearcy, DO

Gracie Rubideaux, MD

Palvinder Garcha, DO

Rob Meyer, MD

American Family Physician. 2024;110(1):74-75.

Author disclosure: No relevant financial relationships.

AMY PEARCY, DO; GRACIE RUBIDEAUX, MD; PALVINDER GARCHA, DO; and ROB MEYER, MD, are family physicians at Multicare East Pierce Family Medicine, Puyallup, Wash.

Address correspondence to Amy Pearcy, DO, at ajpearcy@multicare.org.

Author disclosure: No relevant financial relationships.

1.Lei LY, Raj SR, Sheldon RS. Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis. Europace. 2022;24(7):1171-1178.
2.Sheldon R, Faris P, Tang A, et al.; POST 4 investigators. Midodrine for the prevention of vasovagal syncope: a randomized clinical trial. Ann Intern Med. 2021;174(10):1349-1356.
3.Shen WK, Sheldon RS, Benditt DG, et al. 2017 ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society [published correction appears in J Am Coll Cardiol. 2017;70(16):2101–2102]. J Am Coll Cardiol. 2017;70(5):620-663.

Help Desk Answers provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). Members of the network select questions based on their relevance to family medicine. Answers are drawn from an approved set of evidence-based resources and undergo peer review. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www.cebm.net).

The complete database of evidence-based questions and answers is copyrighted by FPIN. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email: questions@fpin.org.

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of FPIN’s Help Desk Answers published in AFP is available at https://www.aafp.org/afp/hda.