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FPIN's Clinical Inquiries
From the Family Practice Inquiries Network

Bupropion for Depression in Adolescents

Annie Gensel, MD
Mario Pucci, MD
Kara A. Frame, MD
Brian Vukelic, MD
Laura Elizabeth Moreno, MD
Eliza Taylor, MPH

American Family Physician. 2024;110(1):77-78.

Author disclosure: No relevant financial relationships.

ANNIE GENSEL, MD; MARIO PUCCI, MD; KARA A. FRAME, MD; BRIAN VUKELIC, MD; LAURA ELIZABETH MORENO, MD; and ELIZA TAYLOR, MPH, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah.

Copyright © Family Physicians Inquiries Network. Used with permission.

Address correspondence to Annie Gensel, MD, at Annie.Gensel@hsc.utah.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Overberg A, Morton S, Wagner E, et al. Toxicity of bupropion overdose compared with selective serotonin reuptake inhibitors. Pediatrics. 2019;144(2):e20183295.
  2. 2.Kweon K, Kim HW. Effectiveness and safety of bupropion in children and adolescents with depressive disorders: a retrospective chart review. Clin Psychopharmacol Neurosci. 2019;17(4):537-541.
  3. 3.Sheridan DC, Lin A, Horowitz BZ. Suicidal bupropion ingestions in adolescents: increased morbidity compared with other antidepressants. Clin Toxicol (Phila). 2018;56(5):360-364.
  4. 4.Lee SY, Wang LJ, Yang YH, et al. The comparative effectiveness of antidepressants for youths with major depressive disorder: a nationwide population-based study in Taiwan. Ther Adv Chronic Dis. 2022;13 :20406223221098114.
  5. 5.Cortese S, Adamo N, Del Giovane C, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018;5(9):727-738.

Clinical Inquiries provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). Members of the network select questions based on their relevance to family medicine. Answers are drawn from an approved set of evidence-based resources and undergo peer review. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www.cebm.net).

The complete database of evidence-based questions and answers is copyrighted by FPIN. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email questions@fpin.org.

Copyright © Family Physicians Inquiries Network. Used with permission.

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of FPIN’s Clinical Inquiries published in AFP is available at https://www.aafp.org/afp/fpin.

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Midodrine as a Treatment Option for Recurrent Vasovagal Syncope
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