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Point-of-Care Guides

Predicting Bleeding Risk in Patients With Atrial Fibrillation Who Are Taking Direct Oral Anticoagulants

Lindy Krebs, MD
Aaron Saguil, MD, MPH

American Family Physician. 2024;110(6):639-640.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

LINDY KREBS, MD, and AARON SAGUIL, MD, MPH, University of Florida College of Medicine, Gainesville

Address correspondence to Lindy Krebs, MD, at lindywilliams@ufl.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Joglar JA, Chung MK, Armbruster AL, et al.; Peer Review Committee Members. 2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(1):e1-e156.
  2. 2.Hindricks G, Potpara T, Dagres N, et al.; ESC Scientific Document Group. 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373-498.
  3. 3.Aggarwal R, Ruff CT, Virdone S, et al. Development and validation of the DOAC score: a novel bleeding risk prediction tool for patients with atrial fibrillation on direct-acting oral anticoagulants. Circulation. 2023;148(12):936-946.
  4. 4.Xu Y, Gomes T, Wells PS, et al. Evaluation of definitions for oral anticoagulant–associated major bleeding: a population-based cohort study. Thromb Res. 2022;213:57-64.
  5. 5.Campos-Staffico AM, Jacoby JP, Dorsch MP, et al. Risk scores for major bleeding from direct oral anticoagulants: comparing predictive performance in patients with atrial fibrillation. Res Pract Thromb Haemost. 2023;8(1):102285.
  6. 6.Gaboreau Y, Frappé P, Vermorel C, et al.; CACAO study investigators. Oral anticoagulant safety in family practice: prognostic accuracy of bleeding risk scores (from the CACAO study). Fam Pract. 2024;41(1):9-17.

This guide is one in a series that offers evidence-based tools to assist family physicians in improving their decision-making at the point of care.

This series is coordinated by Mark H. Ebell, MD, MS, deputy editor for evidence-based medicine.

A collection of Point-of-Care Guides published in AFP is available at https://www.aafp.org/afp/poc.

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