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FPIN's Clinical Inquiries
From the Family Practice Inquiries Network

Antibiotic Treatment for Uncomplicated Acute Appendicitis in Children

Timothy Mott, MD
Carrie Gray, DO

American Family Physician. 2025;111(1):75-76.

Author disclosure: No relevant financial relationships.

TIMOTHY MOTT, MD, and CARRIE GRAY, DO, Baldwin Health Family Medicine Residency, Foley, Alabama

Address correspondence to Timothy Mott, MD, at timothy_mott@chs.net.

Author disclosure: No relevant financial relationships.

  1. 1.Lamm R, Kumar SS, Collings AT, et al. Diagnosis and treatment of appendicitis: systematic review and meta-analysis. Surg Endosc. 2023;37(12):8933-8990.
  2. 2.Sajjad MN, Naumeri F, Hina S. Non-operative treatment versus appendectomy for acute uncomplicated appendicitis: a randomized controlled trial. Pak J Med Sci. 2021;37(5):1276-1281.
  3. 3.Lipsett SC, Monuteaux MC, Shanahan KH, et al. Nonoperative management of uncomplicated appendicitis. Pediatrics. 2022;149(5):e2021054693.
  4. 4.Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020;15(1):27.

Clinical Inquiries provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). Members of the network select questions based on their relevance to family medicine. Answers are drawn from an approved set of evidence-based resources and undergo peer review. The strength of recommendations and the level of evidence for individual studies are rated using criteria developed by the Evidence-Based Medicine Working Group (https://www.cebm.net).

The complete database of evidence-based questions and answers is copyrighted by FPIN. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email questions@fpin.org.

Copyright © Family Physicians Inquiries Network. Used with permission.

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of FPIN’s Clinical Inquiries published in AFP is available at https://www.aafp.org/afp/fpin.

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