Metformin to Decrease Mortality in Patients With Prediabetes

Charla Allen; Kayden Barber; Brian Mallory; Annalee Toti

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FPIN's Help Desk Answers

Metformin to Decrease Mortality in Patients With Prediabetes

Charla Allen, MD

Kayden Barber, MD

Brian Mallory, MD

Annalee Toti, MD

American Family Physician. 2025;112(1):79-80.

Author disclosure: No relevant financial relationships.

CHARLA ALLEN, MD; KAYDEN BARBER, MD; BRIAN MALLORY, MD; and ANNALEE TOTI, MD, Texas Tech University Health Sciences Center Family Medicine Residency Program, Lubbock

Address correspondence to Charla Allen, MD, at Charla.Allen@ttuhsc.edu.

Author disclosure: No relevant financial relationships.

1.Echouffo-Tcheugui JB, Perreault L, Ji L, et al. Diagnosis and management of prediabetes: a review. JAMA. 2023;329(14):1206-1216.
2.Lee CG, Heckman-Stoddard B, Dabelea D, et al.; Diabetes Prevention Program Research Group. Effect of metformin and lifestyle interventions on mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study. Diabetes Care. 2021;44(12):2775-2782.
3.Goldberg RB, Orchard TJ, Crandall JP, et al.; Diabetes Prevention Program Research Group. Effects of long-term metformin and lifestyle interventions on cardiovascular events in the Diabetes Prevention Program and its outcome study. Circulation. 2022;145(22):1632-1641.

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