Progressive Skin Discoloration

Mark Luff; Erin Wofford; Ben Stillman

Pruritic Rash Exacerbated by Steroid Cream

Nov 2025

Perfluorohexyloctane Ophthalmic Solution (Miebo) for Dry Eye

Photo Quiz

Progressive Skin Discoloration

This photo quiz was corrected on November 24, 2025.

Mark Luff, MD

Erin Wofford, MD

Ben Stillman, DO

American Family Physician. 2025;112(5):563-564.

Author disclosure: No relevant financial relationships.

MARK LUFF, MD; ERIN WOFFORD, MD; and BEN STILLMAN, DO, Indiana University School of Medicine Family Medicine Residency Program, Jasper

Address correspondence to Mark Luff, MD, at mluff@mhhcc.org.

Author disclosure: No relevant financial relationships.

1.Shute L, Walkty A, Embil JM. Minocycline-induced cutaneous hyperpigmentation. CMAJ. 2020;192(34):E981.
2.Johnson RA, Wolff K, Fitzpatrick TB. Fitzpatrick’s Color Atlas and Synopsis of Clinical Dermatology. 6th ed. McGraw-Hill; 2009.
3.Habif TP. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 6th ed. Elsevier; 2016.
4.Nicholls SC. Sequelae of untreated venous insufficiency. Semin Intervent Radiol. 2005;22(3):162-168.

The editors of AFP welcome submissions for Photo Quiz. Guidelines for preparing and submitting a Photo Quiz manuscript can be found in the Authors' Guide at https://www.aafp.org/afp/photoquizinfo. To be considered for publication, submissions must meet these guidelines. Email submissions to afpphoto@aafp.org.

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of Photo Quiz published in AFP is available at https://www.aafp.org/afp/photoquiz.