Previous article
Long-Term Use of Obesity Management Medications: Challenges and Discontinuation Strategies
Feb 2026
Next article
Alzheimer Disease, Polycystic Ovary Syndrome, Carpal Tunnel Syndrome, Pyogenic Granulomas, Depression in Heart Disease, Urinary Tract Infections
Medicine by the Numbers

PPIs for Prevention of NSAID-Induced Gastric or Duodenal Ulcers and Dyspepsia

Megan D. Rodgers, MD
Michael D. North, MD

American Family Physician. 2026;113(2):124-125.

Author disclosure: No relevant financial relationships.

MEGAN D. RODGERS, MD, and MICHAEL D. NORTH, MD, Medical University of South Carolina, Charleston

Address correspondence to Megan D. Rodgers, MD, at rodgerme@musc.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Garegnani L, Oltra G, Burgos MA, et al. Proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug-induced ulcers and dyspepsia. Cochrane Database Syst Rev. 2025(5):CD014585.
  2. 2.Massó González EL, Patrignani P, Tacconelli S, et al. Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding. Arthritis Rheum. 2010;62(6):1592-1601.
  3. 3.García Rodríguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994;343(8900):769-772.
  4. 4.Scheiman JM. The use of proton pump inhibitors in treating and preventing NSAID-induced mucosal damage. Arthritis Res Ther. 2013;15(suppl 3):S5.
  5. 5.Sheen E, Triadafilopoulos G. Adverse effects of long-term proton pump inhibitor therapy. Dig Dis Sci. 2011;56(4):931-950.

Copyright ©2026 MD Aware, LLC (theNNT.com). Used with permission.

This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

A collection of Medicine by the Numbers published in AFP is available at https:// www.aafp.org/afp/mbtn.

Previous article
Long-Term Use of Obesity Management Medications: Challenges and Discontinuation Strategies
Feb 2026
Next article
Alzheimer Disease, Polycystic Ovary Syndrome, Carpal Tunnel Syndrome, Pyogenic Granulomas, Depression in Heart Disease, Urinary Tract Infections

Current issue

May 2026

May 2026

Copyright © 2026 by the American Academy of Family Physicians.

This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. See permissions for copyright questions and/or permission requests.