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FPIN's Clinical Inquiries
From the Family Practice Inquiries Network

Beta Blockers to Improve Post-MI Outcomes in Patients Without HF

Wesley Roten, MD
Anne Mounsey, MD
Ryan Paulus, DO

American Family Physician. 2026;113(4):386-387.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

WESLEY ROTEN, MD; ANNE MOUNSEY, MD; and RYAN PAULUS, DO, University of North Carolina at Chapel Hill

Address correspondence to Ryan Paulus, DO, at ryan_paulus@med.unc.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Ibanez B, Latini R, Rossello X, et al.; REBOOT-CNIC Investigators. Beta-blockers after myocardial infarction without reduced ejection fraction. N Engl J Med. 2025;393(19):1889-1900.
  2. 2.Munkhaugen J, Kristensen AMD, Halvorsen S, et al.; BETAMI–DAN BLOCK Investigators. Beta-blockers after myocardial infarction in patients without heart failure. N Engl J Med. 2025;393(19):1901-1911.
  3. 3.Silvain J, Cayla G, Ferrari E, et al.; ABYSS Investigators of the ACTION Study Group. Beta-blocker interruption or continuation after myocardial infarction. N Engl J Med. 2024;391(14):1277-1286.
  4. 4.Yndigegn T, Lindahl B, Mars K, et al.; REDUCE-AMI Investigators. Beta-blockers after myocardial infarction and preserved ejection fraction. N Engl J Med. 2024;390(15):1372-1381.
  5. 5.Kim Y, Byun S, Kim HY, et al. Long-term beta-blocker therapy after myocardial infarction without heart failure in the reperfusion era–systemic review and meta-analysis. J Cardiovasc Pharmacol. 2022;79(5):650-654.
  6. 6.Hu MJ, Wang XN, Tan JS, et al. Association of beta-blocker therapy at discharge with clinical outcomes in patients without heart failure or left ventricular systolic dysfunction after acute coronary syndrome: an updated systematic review and meta-analysis. Arch Cardiovasc Dis. 2022;115(12):637-646.
  7. 7.Virani SS, Newby LK, Arnold SV, et al.; Peer Review Committee Members. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2023;148(9):e9-e119.

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Copyright © Family Physicians Inquiries Network. Used with permission.

This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor.

A collection of FPIN’s Clinical Inquiries published in AFP is available at https://www.aafp.org/afp/fpin.

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