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Cochrane for Clinicians

Atypical Antipsychotics to Manage Behavioral Symptoms in Autism Spectrum Disorder

Anjani Urban, MD,
Kimberly Schiel, MD, MA,
Kento Sonoda, MD,
Saint Louis University School of Medicine, St. Louis, Missouri

American Family Physician. 2026;113(5):428-429.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

  1. 1.Meza N, Franco JV, Sguassero Y, et al. Atypical antipsychotics for autism spectrum disorder: a network meta-analysis. Cochrane Database Syst Rev. 2025(5):CD014965.
  2. 2.Zeidan J, Fombonne E, Scorah J, et al. Global prevalence of autism: a systematic review update. Autism Res. 2022;15(5):778-790.
  3. 3.Bertelli MO, Forte L, Bianco A. Updates in the care of youths with intellectual disability and autism spectrum disorder. Curr Opin Psychiatry. 2023;36(6):455-460.
  4. 4.Deb SS, Limbu B, Unwin G, et al. Short-term psycho-education for caregivers to reduce overmedication of people with intellectual disabilities (SPECTROM): development and field testing. Int J Environ Res Public Health. 2021;18(24):13161.
  5. 5.Volkmar F, Siegel M, Woodbury-Smith M; American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI). Practice parameter for the assessment and treatment of children and adolescents with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2014;53(2):237-257.
  6. 6.Aman MG, Singh NN. Aberrant Behavior Checklist: Manual. Slosson Educational Publications; 1986.
  7. 7.Goodman WK, Price LH, Rasmussen SA, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. 1989;46(11):1006-1011.
  8. 8.Fuentes J, Hervás A, Howlin P; ESCAP ASD Working Party. ESCAP practice guidance for autism: a summary of evidence-based recommendations for diagnosis and treatment. Eur Child Adolesc Psychiatry. 2021;30(6):961-984.

These are summaries of reviews from the Cochrane Library.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at https://www.aafp.org/afp/cochrane.

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