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Cochrane for Clinicians

NSAIDs to Manage Acute Renal Colic Pain

James Wilcox, MD,
College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

American Family Physician. 2026;113(5):429.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

  1. 1.Afshar K, Gill J, Mostafa H, et al. Nonsteroidal anti-inflammatory drugs (NSAIDs) for acute renal colic. Cochrane Database Syst Rev. 2025(3):CD006027.
  2. 2.Afshar K, Jafari S, Marks AJ, et al. Nonsteroidal anti-inflammatory drugs (NSAIDs) and non-opioids for acute renal colic. Cochrane Database Syst Rev. 2015(6):CD006027.
  3. 3.Gu HY, Luo J, Wu JY, et al. Increasing nonsteroidal anti-inflammatory drugs and reducing opioids or paracetamol in the management of acute renal colic: based on three-stage study design of network meta-analysis of randomized controlled trials. Front Pharmacol. 2019;10:96.
  4. 4.European Association of Urology. EAU guidelines on urolithiasis. 2025. Accessed September 25, 2025. https://uroweb.org/guidelines/urolithiasis/chapter/guidelines
  5. 5.National Institute for Health and Care Excellence (NICE). Renal and ureteric stones: assessment and management. NICE guideline NG118. January 8, 2019. Accessed September 25, 2025. https://www.nice.org.uk/guidance/ng118/chapter/Recommendations#pain-management

These are summaries of reviews from the Cochrane Library.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at https://www.aafp.org/afp/cochrane.

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