Norgestrel 0.075 mg (Opill) is a once-daily progestin-only oral contraceptive. It is labeled for use as an over-the-counter medication to reduce the likelihood of pregnancy.¹

The terms woman and women may be used in this article to reflect original study populations of cisgender females, but the research may be extended to all people who could become pregnant.

Safety

When used as directed, norgestrel is safe for most women with reproductive potential. It should not be used in people who have or have had breast cancer because norgestrel may stimulate breast cancer cell growth by activating the estrogen receptor.² It is unclear whether oral use of norgestrel for contraception can increase lifetime risk of breast cancer in women.³ Norgestrel should not be used by women who have undiagnosed abnormal uterine bleeding or in women with benign or malignant liver tumors.⁴