Perfluorohexyloctane Ophthalmic Solution (Miebo) for Dry Eye

Stefanie C. Nigro; Timothy Lishnak

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Nov 2025

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STEPS

New Drug Reviews

Perfluorohexyloctane Ophthalmic Solution (Miebo) for Dry Eye

Stefanie C. Nigro, PharmD, BCACP

Timothy Lishnak, MD

American Family Physician. 2025;112(5):566-567.

Author disclosure: No relevant financial relationships.

STEFANIE C. NIGRO, PharmD, BCACP, University of Connecticut School of Pharmacy, Storrs, and The Family Medicine Clinic at Asylum Hill, Hartford

TIMOTHY LISHNAK, MD, University of Connecticut School of Medicine, Farmington, and The Family Medicine Clinic at Asylum Hill, Hartford

Address correspondence to Stefanie C. Nigro, PharmD, BCACP, at stefanie.nigro@uconn.edu.

Author disclosure: No relevant financial relationships.

1.DailyMed. Drug label information. Miebo—perfluorohexyloctane solution. Updated July 18, 2024. Accessed March 20, 2025. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6b283c02-7df4-4c00-951b-555cddffe77c
2.Tauber J, Berdy GJ, Wirta DL, et al.; GOBI Study Group. NOV03 for dry eye disease associated with meibomian gland dysfunction: results of the randomized phase 3 GOBI study. Ophthalmology. 2023;130(5):516-524.
3.Sheppard JD, Kurata F, Epitropoulos AT, et al.; MOJAVE Study Group. NOV03 for signs and symptoms of dry eye disease associated with meibomian gland dysfunction: the randomized phase 3 MOJAVE study. Am J Ophthalmol. 2023;252:265-274.
4.Protzko EE, Segal BA, Korenfeld MS, et al. Long-term safety and efficacy of perfluorohexyloctane ophthalmic solution for the treatment of patients with dry eye disease: the KALAHARI study. Cornea. 2024;43(9):1100-1107.

STEPS new drug reviews cover Safety, Tolerability, Effectiveness, Price, and Simplicity. Each independent review is provided by authors who have no financial association with the drug manufacturer.

This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor.

A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps.