Am Fam Physician. 2025;112(5):566-567
Author disclosure: No relevant financial relationships.
| Drug | Dosage | Dose form | Cost* |
|---|---|---|---|
| Perfluorohexyloctane ophthalmic solution (Miebo) | One drop in the affected eye 4 times per day | Ophthalmic solution, 3-mL bottle | $850 |
Perfluorohexyloctane ophthalmic solution (Miebo) is labeled for the treatment of dry eye (keratoconjunctivitis sicca) in adults. It is a water- and preservative-free drop that forms a stable, moisture-retaining layer on the surface of the eye to prevent tear evaporation.1
SAFETY
Perfluorohexyloctane ophthalmic solution is safe for short- and long-term use in adults, with a safety profile comparable to that of hypotonic saline. In two studies, each lasting 8 weeks, 614 participants using the solution four times daily in both eyes reported no serious ocular or nonocular adverse events.2,3 One participant experienced severe eye irritation that led to treatment discontinuation.3 A 52-week extension study found no serious ocular adverse effects among solution users.4
Subscribe
From $180- Immediate, unlimited access to all AFP content
- More than 125 CME credits/year
- AAFP app access
- Print delivery available
Issue Access
$59.95- Immediate, unlimited access to this issue's content
- CME credits
- AAFP app access
- Print delivery available