Introduction

Eosinophilic esophagitis (EoE) is a chronic, allergen-induced, immune-mediated disease characterized by esophageal dysfunction and eosinophil-predominant esophageal infiltration.^1,2 EoE has only recently been recognized as a distinct clinical entity, with its incidence and prevalence rising sharply over the past two decades.¹

EoE affects patients across all age groups and occurs more frequently in males. Earlier assumptions that EoE primarily occurs in White individuals likely reflect bias in study participation and reporting, rather than true biologic differences.^3,4

Patients with EoE are often found to have one or more atopic comorbidities.⁵ Familial clustering supports a contribution from genetic susceptibility, but twin and family studies show that shared environmental factors play a far greater role than genetics in disease development.^6,7