Symplicity™ blood pressure procedure referral resource

October 8, 2026
Provided by AAFP partner
Abstract blue and teal illustration of the kidneys and urinary tract showing renal denervation.

Hypertension remains one of the most significant and difficult cardiovascular risk factors to manage in clinical practice. Despite lifestyle recommendations and the availability of multiple antihypertensive medications, many patients continue to have uncontrolled blood pressure due to factors such as medication burden, side effects, adherence challenges, and comorbid conditions. The referral brochure addresses this ongoing treatment gap by introducing renal denervation as an additional treatment option for appropriate patients with hypertension whose blood pressure remains uncontrolled despite current management strategies.

This resource provides family physicians with an overview of the Symplicity™ blood pressure procedure, a minimally invasive renal denervation procedure designed to complement lifestyle modifications and medication therapy. The brochure explains how the procedure works; summarizes clinical evidence supporting significant, safe, and sustained blood pressure reductions; and outlines patient selection considerations. It also includes practical information to help physicians identify patients who may benefit from referral, including those who are unable to achieve blood pressure control with medications alone, experience medication side effects, have adherence challenges, or express interest in non-pharmacologic treatment options.

In addition to reviewing clinical data, the brochure offers guidance on patient screening, provides examples of common patient profiles that may be appropriate for consideration, and connects clinicians with resources to facilitate referral and shared decision-making conversations. Physicians can also learn how to connect patients with experienced proceduralists and access educational materials, patient resources, and support services designed to assist with integrating this treatment option into practice.

The brochure may be particularly valuable for primary care clinicians seeking additional options for patients whose hypertension remains difficult to control and for those looking to better understand the evolving role of renal denervation in hypertension management. Through evidence-based information and practical referral guidance, this resource helps physicians evaluate whether the Symplicity procedure may be an appropriate addition to their treatment discussions with eligible patients.

About Medtronic Renal Denervation

Medtronic is committed to advancing hypertension care through innovative therapies that expand treatment options for patients and clinicians. The Medtronic Renal Denervation team supports clinician education, patient resources, referral pathways, and ongoing efforts to improve blood pressure control and reduce cardiovascular risk through evidence-based renal denervation therapy.

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