Effect of Vitamin B12 Supplementation in Pregnancy on Perinatal Outcomes

Victoria A. Sullivan, MD
Russell S. Blackwelder, MD, MDiv, CMD

American Family Physician. 2024;110(5):462A-462B.

Author disclosure: No relevant financial relationships.

VICTORIA A. SULLIVAN, MD, and RUSSELL S. BLACK-WELDER, MD, MDiv, CMD, Medical University of South Carolina, Charleston

Copyright © 2024 MD Aware, LLC (theNNT.com). Used with permission.

Address correspondence to Victoria A. Sullivan, MD, at sullivvi@musc.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Rogne T, Tielemans MJ, Chong MFF, et al. Associations of maternal vitamin B12 concentration in pregnancy with the risks of preterm birth and low birth weight: a systematic review and meta-analysis of individual participant data. Am J Epidemiol. 2017;185(3):212-223.
  2. 2.Finkelstein JL, Layden AJ, Stover PJ. Vitamin B-12 and perinatal health. Adv Nutr. 2015;6(5):552-563.
  3. 3.Abdelwahab OA, Abdelaziz A, Diab S, et al. Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: a systematic review and network meta-analysis. Ir J Med Sci. 2024;193(3):1621-1639.
  4. 4.Finkelstein JL, Fothergill A, Venkatramanan S, et al. Vitamin B12 supplementation during pregnancy for maternal and child health outcomes. Cochrane Database Syst Rev. 2024(1):CD013823.

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This series is coordinated by Christopher W. Bunt, MD, AFP assistant medical editor, and the NNT Group.

A collection of Medicine by the Numbers published in AFP is available at https:// www.aafp.org/afp/mbtn.

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