Antidepressants vs Placebo for Moderate to Severe Generalized Anxiety Disorder

Taran W. Silva, DO,

Anna Milliren, DO,

Travis AFB, California; Uniformed Services University of the Health Sciences, Bethesda, Maryland

American Family Physician. 2025;112(4):377-378.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

1.Kopcalic K, Arcaro J, Pinto A, et al. Antidepressants versus placebo for generalised anxiety disorder (GAD). Cochrane Database Syst Rev. 2025(1):CD012942.
2.Wittchen HU, Zhao S, Kessler RC, et al. DSM-III-R generalized anxiety disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51(5):355-364.
3.Terlizzi EP, Villarroel MA. Symptoms of generalized anxiety disorder among adults: United States, 2019. NCHS Data Brief. 2020;378:1-8.
4.Generalised anxiety disorder and panic disorder in adults: management (CG113). Updated June 15, 2020. National Institute for Health and Care Excellence (NICE); 2020.

These are summaries of reviews from the Cochrane Library.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at https://www.aafp.org/afp/cochrane.