Articles
Diagnosis and Management of Tinea Infections
Tinea infections are common superficial fungal infections caused by dermatophyte molds. Diagnostic testing can help differentiate tinea infection from other similar-appearing conditions. Treatment typically includes oral or topical antifungals; however, the use of combination…
Uterine Fibroids: Rapid Evidence Review
Most uterine fibroids are asymptomatic, but symptoms include bulk symptoms due to increased uterine size, abnormal uterine bleeding, pelvic pain, and infertility. Evaluation of symptoms should include abdominal, speculum, and bimanual pelvic examinations. Initial imaging is…
Nail Abnormalities
Nail abnormalities can involve surface texture irregularities, color changes, defects of nail plate attachment, tumors, or a combination. Nail clippings, ultrasonography, dermoscopy, and biopsy are useful for diagnosing nail abnormalities. Dermoscopy can help triage lesions and…
Slipped Capital Femoral Epiphysis: Rapid Evidence Review
Slipped capital femoral epiphysis is associated with potentially serious lifelong complications and sequelae. Patients should be immediately placed into non–weight-bearing status and urgently referred to an orthopedic surgeon for surgical fixation to limit progression.
Venous Thromboembolism: Diagnosis and Treatment
Venous thromboembolism, a common and potentially life-threatening condition, encompasses two major clinical conditions: deep venous thrombosis and pulmonary embolism. Clinical prediction rules; d-dimer assay screening, if indicated; and imaging results assist in diagnosis.
Heart Failure With Preserved Ejection Fraction
Although the overall incidence of heart failure appears to be decreasing in the United States, the incidence of heart failure with preserved ejection fraction continues to rise. Treatment focuses on symptom control and management of comorbid conditions, including hypertension…
Inside AFP
Evolving Treatment of Opioid Use Disorder in American Family Physician
American Family Physician has reflected the major changes in the understanding and treatment of opioid use disorder in the past 75 years.
Editorials
Too Many Colonoscopies
There is no evidence that colonoscopy is any more effective than the fecal immunochemical test.
Graham Center Policy One-Pager
Community-Based Residency Training for Primary Care Physicians
Academic centers have been the central training location for residency programs since the 1910 Flexner Report. Despite the continued shortage of primary care physicians, the graduate medical education system is resistant to change. Only 11.7% of graduating resident physicians…
AFP Clinical Answers
Bleeding Risk With Atrial Fibrillation, Prostate Cancer Screening, Alzheimer Disease, Concussion, Melanoma, Rheumatoid Arthritis
Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.
Medicine by the Numbers
Glucagon-Like Peptide-1 Receptor Agonists for People With Chronic Kidney Disease and Diabetes
We have assigned a color recommendation of yellow (unclear benefits) for the use of GLP-1 receptor agonists in patients with diabetes and CKD. Although moderate-certainty evidence suggests a reduction in major adverse cardiovascular events and all-cause mortality, the lack of…
Cochrane for Clinicians
Antidepressants vs Placebo for Moderate to Severe Generalized Anxiety Disorder
More patients with generalized anxiety disorder achieve a 50% reduction in self-reported anxiety symptoms by using antidepressants compared with placebo. Fewer participants who use antidepressants discontinue treatment due to lack of effectiveness; more participants discontinue…
Safety and Effectiveness of Intravenous vs Oral Iron for Treatment of Anemia in the Prenatal and Postpartum Periods
In the prenatal setting, treatment of iron deficiency anemia with intravenous iron rather than oral iron may slightly increase the hemoglobin level 3 to 6 weeks after treatment and around the time of birth; however, there is no significant effect on postpartum hemorrhage, need…
Photo Quiz
Child With a Single Small Lesion
A 5-year-old girl presented with a single small lesion on her back.
A Woman With Generalized Hair Loss
A 35-year-old woman presented with generalized hair thinning.
Diary of a Family Physician
Diary of a Family Physician
First-person accounts from the front lines of family medicine.
FPIN's Clinical Inquiries
Nicotine e-Cigarettes as a Strategy for Smoking Cessation
Use of nicotine e-cigarettes increases tobacco smoking cessation rates compared with use of nicotine replacement therapy, non-nicotine e-cigarettes, behavioral support only, and no support. Nicotine e-cigarettes are as effective as varenicline (Chantix) for tobacco smoking…
Lown Right Care
Overuse of Colorectal Cancer Screening and Surveillance
A collaboration between AFP and the Lown Institute promotes a vision of delivering health care that is based on the evidence, balanced in its approach, and focused on the patient.
POEMs
Practice Guidelines
Management of Major Depressive Disorder in Adults: Guidelines From CANMAT
The Canadian Network for Mood and Anxiety Treatments (CANMAT) has published updated guidelines on management of major depressive disorder in adults.
Letters to the Editor
When a Cat Bite Mimics Cancer: A Reminder to Consider Zoonotic Infections
Letter to the Editor
Corrections
Corrections
More than one correct answer choice in CME Quiz. The March 2025 CME Quiz (p. 206) included more than one correct answer choice for a question about the article “Pacifiers: Common Questions and Answers.” The online CME Quiz has been corrected and there is now only one correct…
Corrections
Incorrect symbol. The article “Vaccines for Measles, Mumps, Rubella, and Varicella in Children and Adolescents” (Cochrane for Clinicians, July 2025, p. 25) incorrectly included negative signs in relative risk values. The online version of the article has been corrected.