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Cochrane for Clinicians

Calcium Supplementation for Improving Pregnancy and Infant Outcomes (Other Than for Preventing or Treating Hypertension)

Tara Devaraj, MD,
Bernadatte G. Gilbert, MD,
Penn State Health Milton S. Hershey Medical Center/Penn State College of Medicine, Hershey, Pennsylvania

American Family Physician. 2026;113(1):19-20.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

  1. 1.Kongwattanakul K, Duangkum C, Ngamjarus C, et al. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database Syst Rev. 2024(11):CD007079.
  2. 2.Hofmeyr GJ, Lawrie TA, Atallah ÁN, et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 2018(10):CD001059.
  3. 3.WHO recommendation: calcium supplementation during pregnancy for prevention of pre-eclampsia and its complications. World Health Organization; 2018. Accessed March 20, 2025. https://www.who.int/publications/i/item/9789241550451
  4. 4.Woo Kinshella ML, Sarr C, Sandhu A, et al. Calcium for pre-eclampsia prevention: a systematic review and network meta-analysis to guide personalised antenatal care. BJOG. 2022;129(11):1833-1843.
  5. 5.Dwarkanath P, Muhihi A, Sudfeld CR, et al. Two randomized trials of low-dose calcium supplementation in pregnancy. N Engl J Med. 2024;390(2):143-153.
  6. 6.Gestational hypertension and preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol. 2020;135(6):e237-e260.

These are summaries of reviews from the Cochrane Library.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at https://www.aafp.org/afp/cochrane.

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