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STEPS
New Drug Reviews

Vonoprazan (Voquezna) to Treat Erosive Esophagitis and GERD and Eradicate H pylori

William Dabbs, MD
Shaunta' Chamberlin, PharmD

American Family Physician. 2026;113(1):89-90.

Author disclosure: No relevant financial relationships.

WILLIAM DABBS, MD, FAAFP, and SHAUNTA' CHAMBERLIN, PharmD, FCCP, University of Tennessee Health Science Center College of Medicine, Knoxville

Address correspondence to William Dabbs, MD, FAAFP, at wdabbs@utmck.edu.

Author disclosure: No relevant financial relationships.

  1. 1.Daily Med. Drug label information. Voquezna—vonoprazan fumarate tablet. Accessed October 17, 2025. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0cc52ac5-77ec-4d66-a770-762a1a960914
  2. 2.National Institute of Child Health and Human Development. Drugs and Lactation Database (LactMed) [Internet]. Vonoprazan. Updated September 15, 2025. Accessed October 17, 2025. https://www.ncbi.nlm.nih.gov/books/NBK581487
  3. 3.Chey WD, Mégraud F, Laine L, et al. Vonoprazan triple and dual therapy for Helicobacter pylori infection in the United States and Europe: randomized clinical trial. Gastroenterology. 2022;163(3):608-619.
  4. 4.Laine L, DeVault K, Katz P, et al. Vonoprazan versus lansoprazole for healing and maintenance of healing of erosive esophagitis: a randomized trial. Gastroenterology. 2023;164(1):61-71.
  5. 5.Laine L, Spechler S, Yadlapati R, et al. Vonoprazan is efficacious for treatment of heartburn in non-erosive reflux disease: a randomized trial. Clin Gastroenterol Hepatol. 2024;22(11):2211-2220.e10.

STEPS new drug reviews cover Safety, Tolerability, Effectiveness, Price, and Simplicity. Each independent review is provided by authors who have no financial association with the drug manufacturer.

This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor.

A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps.

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