Effect of Adrenergic Agonist Oral Decongestants on Blood Pressure

Tracy Johns, PharmD, MSMS, BCACP,

Julia Jenkins, MD, FAAFP, DipABLM,

USF Morsani College of Medicine, Tampa

American Family Physician. 2026;113(6):534.

Author disclosure: No relevant financial relationships.

This clinical content conforms to AAFP criteria for CME.

Author disclosure: No relevant financial relationships.

1.Chan JJ, Chan M, Wright JM. Effect of adrenergic agonist oral decongestants on blood pressure. Cochrane Database Syst Rev. 2025(3):CD007895.
2.Centers for Disease Control and Prevention, National Center for Health Statistics. FastStats. Hypertension. Accessed September 21, 2025. https://www.cdc.gov/nchs/fastats/hypertension.htm
3.US Food and Drug Administration. Phenylpropanolamine (PPA) information page. Updated December 22, 2005. Accessed November 2, 2025. https://www.fda.gov/drugs/information-drug-class/phenylpropanolamine-ppa-information-page
4.Jones DW, Ferdinand KC, Taler SJ, et al.; Writing Committee Members. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2025;152(11):e114-e218.

These are summaries of reviews from the Cochrane Library.

This series is coordinated by Corey D. Fogleman, MD, assistant medical editor.

A collection of Cochrane for Clinicians published in AFP is available at https://www.aafp.org/afp/cochrane.