June 2026

Gambling disorder is often underdiagnosed. Case-finding using a direct question about gambling in patients at increased risk is recommended. Pharmacotherapy, psychotherapy, and self-help groups, such as Gamblers Anonymous, may help reduce gambling severity.

Insulin treatment remains a significant but complex aspect of managing type 2 diabetes. To optimize insulin use in the outpatient setting, family physicians must consider strategies for initiation, titration, and adherence.

Pacemakers are indicated to improve symptoms of bradycardia, prevent high-degree atrioventricular block from degenerating into complete heart block, and promote ventricular synchrony and improve survival in select patients.

For mild or moderate cases of nausea and vomiting in pregnancy, first-line treatment is vitamin B6 with or without doxylamine. If it is ineffective, or in more severe cases, treatment can be advanced to alternative agents, taking care to balance patient-specific risk factors…

Recurrent urinary tract infections lead to significant patient morbidity, increased health care use, and antibiotic resistance concerns. These factors underscore the need to approach management holistically, balancing treatment, prevention, and antimicrobial stewardship with a…

Metabolic dysfunction–associated steatotic liver disease is an increasinglycommon cause of chronic liver disease and is strongly associated withcardiovascular disease. Management includes lifestyle interventions, weightloss, and pharmacologic treatment.

Population-based universal screening for MASLD is not recommended because evidence of benefit is lacking. Less than 10% of patients with MASLD progress to severe fibrosis or cirrhosis with increased risk of developing hepatocellular carcinoma.

Primary care clinicians are critical to delivering preventive care. Federal support for PrEP and primary care prescriptions are essential for continued progress toward ending the HIV epidemic in the United States.

Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.

A color recommendation of green (benefits greater than harms) has been assigned for the use of desmopressin in children with nocturnal enuresis.

Adrenergic agonist oral decongestants taken for at least 7 days have little to no effect on blood pressure compared with placebo. These medications also appear to have little to no effect on heart rate or withdrawals due to adverse effects.

Use of hormonal contraception for up to 18 months, including medroxyprogesterone depot injection and levonorgestrel implant, in women who are at risk of HIV infection results in little to no difference in HIV acquisition rates compared with a nonhormonal method (ie, cop

First-person accounts from the front lines of family medicine.

A 2-week-old uncircumcised boy was brought in for a well-child visit. His birth history was unremarkable.

A 16-year-old male patient presented with a pruritic rash that had started on his face and spread rapidly to the rest of his body.

Which clinical scoring system is most accurate for risk stratification of acute appendicitis in adults?

The Lumipulse G pTau217/beta-amyloid 1-42 plasma ratio assay (Fujirebio Diagnostics, Sweden) is a blood test used to assist in the diagnosis of Alzheimer disease.

Consistent use of nightly continuous positive airway pressure therapy lowers blood pressure levels in patients with hypertension and obstructive sleep apnea (OSA). Patients with resistant hypertension should be screened for OSA.

A collaboration between AFP and the Lown Institute promotes a vision of delivering health care that is based on the evidence, balanced in its approach, and focused on the patient.

For Post-stent Patients With Atherosclerotic Coronary Vascular Disease Who Are Taking an Anticoagulant, Adding Aspirin Worsens Outcomes

Aerobic Exercise Is the Better Exercise Modality for Knee Osteoarthritis

Study Confirms Benefits of Early Administration of Oseltamivir for Hospitalized Patients With Influenza

Clopidogrel Is Slightly More Effective Than Aspirin for the Secondary Prevention of Cardiovascular and Cerebrovascular Events

The National Institute for Health and Care Excellence published updated guidelines for prevention of falls in adults 65 years and older and those 50 to 64 years of age with a risk factor for falls.

The American Society of Addiction Medicine coordinated the joint development of guidelines for tapering benzodiazepines in adults outside of palliative and end-of-life settings.

Reply: J. Scott Earwood, MD, FAAFP

Omitted data label. In “Aseptic and Bacterial Meningitis: Diagnosis, Treatment, and Prevention” (March 2026, p. 262), glucose level ranges in Table 2 should have been labeled as cerebrospinal fluid to serum glucose ratios. The online version of the article has been corrected.

This activity is supported by the CDC of the HHS, as part of a financial assistance award totaling $1,219,331, with 100% funded by CDC/HHS. The contents are those of the author and do not necessarily represent the official views of, nor an endorsement by, the CDC/HHS or the U.S…