Tradipitant (Nereus) for the Prevention of Motion Sickness

Emily Feng; Keri Bergeson

Menopause and Increased Risk of Metabolic Dysfunction–Associated Steatotic Liver Disease

Jul 2026

Norethindrone Reduced Prolonged Bleeding Related to Etonogestrel Implant

STEPS

New Drug Reviews

Tradipitant (Nereus) for the Prevention of Motion Sickness

Emily Feng, MD

Keri Bergeson, MD

American Family Physician. 2026;114(1):96-97.

Author disclosure: No relevant financial relationships.

EMILY FENG, MD, Tufts University School of Medicine, Boston, Massachusetts

KERI BERGESON, MD, University of Minnesota, Minneapolis

Address correspondence to Emily Feng, MD, at efeng@challiance.org.

Author disclosure: No relevant financial relationships.

1.Daily Med. Drug label information. Nereus—tradipitant capsule. Updated March 25, 2026. Accessed April 2, 2026. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a021ebd-16ac-4354-b4b2-1c3950c091e5
2.Denholm L, Gallagher G. Physiology and pharmacology of nausea and vomiting. Anaesth Intensive Care Med. 2021;22(10):663-666.
3.Polymeropoulos VM, Kiely L, Bushman ML, et al. Motion Syros: tradipitant effective in the treatment of motion sickness; a multicenter, randomized, double-blind, placebo-controlled study. Front Neurol. 2025;16:1550670.
4.National Library of Medicine. Motion Sifnos: a study to investigate the efficacy of tradipitant in subjects affected by motion sickness. Updated May 9, 2026. Accessed May 17, 2026. https://clinicaltrials.gov/study/NCT03772340
5.National Library of Medicine. Motion Serifos: a study to investigate the efficacy of tradipitant in participants affected by motion sickness. Updated April 4, 2026. Accessed May 17, 2026. https://clinicaltrials.gov/study/NCT05903924
6.Goodrx. Accessed May 12, 2026. https://www.goodrx.com

STEPS new drug reviews cover Safety, Tolerability, Effectiveness, Price, and Simplicity. Each independent review is provided by authors who have no financial association with the drug manufacturer.

This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor.

A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps.