Am Fam Physician. 2022;106(5):498
What empiric antibiotic therapy should be considered for CAP in adult outpatients without comorbid conditions?
Empiric antibiotic therapy for community-acquired pneumonia (CAP) in adult outpatients without comorbid conditions should include high-dose amoxicillin, doxycycline, or a macrolide (if local macrolide resistance rates for pneumococcus are less than 25%).
What empiric antibiotic therapy should be considered for CAP in adult outpatients with comorbid conditions?
Amoxicillin/clavulanate (Augmentin) or a third-generation cephalosporin combined with doxycycline or a macrolide, or monotherapy with a respiratory fluoroquinolone is recommended for empiric CAP treatment in adults with comorbid conditions (e.g., heart, lung, liver, or renal disease; diabetes mellitus; alcoholism; malignancy; asplenia).
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