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Am Fam Physician. 2024;109(5):470-471

Author disclosure: No relevant financial relationships.

Soluble fms-like tyrosine kinase-1 (sFlt-1) is a vascular endothelial growth factor and antagonist of placental growth factor (PlGF) that causes vasoconstriction and endothelial damage, which may result in preeclampsia.1 There is no standardized value for the sFlt-1/PlGF ratio in the diagnosis or exclusion of preeclampsia.2,3 The American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine recommend against measurement of these angiogenic markers for diagnosis or exclusion of preeclampsia.4

sFlt-1/PlGF immunoassaysAssist with predicting likelihood of developing preeclampsiaAsymptomatic pregnant patients between 24 weeks and 0 days' and 36 weeks and 6 days' gestation$100
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This series is coordinated by Natasha Pyzocha, DO, contributing editor.

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