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Am Fam Physician. 2023;107(6):578

When should systemic antibiotics be considered for treatment of acute otitis externa?

Systemic antibiotics should be used only if the infection has spread beyond the ear canal or in patients at high risk of worsening infection, such as those who are immunocompromised or have uncontrolled diabetes mellitus.

What medications may be helpful in the treatment of fibromyalgia pain?

Amitriptyline, cyclobenzaprine, duloxetine (Cymbalta), milnacipran (Savella), and pregabalin (Lyrica) are effective for pain in fibromyalgia.

Is pharmacogenomic-guided antidepressant treatment beneficial in the management of major depressive disorder in adults?

Based on a randomized controlled trial of 1,944 patients, pharmacogenomic testing for drug-gene interactions in adults with major depressive disorder resulted in reduced prescribing of medications with potential drug-gene interactions. However, there was no significant difference in symptom remission rates between the gene-tested group and the usual care group at six months.

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