
Am Fam Physician. 2025;111(5):465-466
Author disclosure: No relevant financial relationships.
Zuranolone (Zurzuvae) is an oral medication labeled for the treatment of postpartum depression in adults.1 It is a neuroactive steroid gamma-aminobutyric acid (GABA) type A receptor positive modulator, which enhances the inhibitory effects of GABA at the synaptic GABA type A receptor.

Drug | Dosage | Dose form | Cost of full course* |
---|---|---|---|
Zuranolone (Zurzuvae) | 50 mg once daily in the evening for 14 days | Capsules: 20 mg, 25 mg, 30 mg | $19,000 |
Subscribe
From $165- Immediate, unlimited access to all AFP content
- More than 130 CME credits/year
- AAFP app access
- Print delivery available
Issue Access
$59.95- Immediate, unlimited access to this issue's content
- CME credits
- AAFP app access
- Print delivery available