Berdazimer (Zelsuvmi) for the Treatment of Molluscum Contagiosum

William Dabbs; Shauntá Chamberlin

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Mar 2025

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STEPS

New Drug Reviews

Berdazimer (Zelsuvmi) for the Treatment of Molluscum Contagiosum

William Dabbs, MD, FAAFP

Shauntá Chamberlin, PharmD

American Family Physician. 2025;111(3):263-264.

Author disclosure: No relevant financial relationships.

WILLIAM DABBS, MD, FAAFP, and SHAUNTA’ CHAM-BERLIN, PharmD, University of Tennessee Graduate School of Medicine, Knoxville.

Address correspondence to William Dabbs, MD, FAAFP, at wdabbs@utmck.edu.

Author disclosure: No relevant financial relationships.

1.Cartwright M, Enloe C, Stripling S, et al. Pharmacokinetic profile, safety, and tolerability of topical berdazimer gel, 10.3% in patients with molluscum contagiosum. J Drugs Dermatol. 2022;21(10):1104-1110.
2.Keam SJ. Berdazimer topical gel, 10.3%: first approval. Drugs. 2024;84(3):363-368.
3.Zelsuvmi (berdazimer) topical gel. Highlights of prescribing information. Accessed May 3, 2024. https://zelsuvmi.com/wp-content/uploads/2024/01/ZELSUVMI-Berdazimer-Topical-Gel-10.3.-Prescribing-Information-and-Instructions-for-Use.pdf
4.National Library of Medicine. Drugs and lactation database (LactMed). National Institute of Child Health and Human Development; 2006-. Berdazimer. Updated August 15, 2024. Accessed January 29, 2025. https://www.ncbi.nlm.nih.gov/books/NBK606324/
5.Browning JC, Enloe C, Cartwright M, et al. Efficacy and safety of topical nitric oxide–releasing berdazimer gel in patients with molluscum contagiosum: a phase 3 randomized clinical trial. JAMA Dermatol. 2022;158(8):871-878.
6.Pera Calvi I, Marques IR, Cruz SA, et al. Safety and efficacy of topical nitric oxide–releasing berdazimer gel for molluscum contagiosum clearance: a systematic review and meta-analysis of randomized controlled trials. Pediatr Dermatol. 2023;40(6):1060-1063.

STEPS new drug reviews cover Safety, Tolerability, Effectiveness, Price, and Simplicity. Each independent review is provided by authors who have no financial association with the drug manufacturer.

This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor.

A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps.