• Articles

    Newborn Skin: Part I. Common Rashes and Skin Changes

    Katherine A. M. Snyder, Adam D. Voelckers

    Part I of this article reviews the presentation, prognosis, and treatment of the most common rashes and skin changes that present during the first four weeks of life.

    Newborn Skin: Part II. Birthmarks

    Katherine A. M. Snyder, Adam D. Voelckers

    Part II of this article reviews the identification and management of birthmarks that appear in the neonatal period, with an emphasis on prognosis and appropriate counseling for parents.

    Diabetic Peripheral Neuropathy: Prevention and Treatment

    Scott Bragg, Sarah Tucker Marrison, Sean Haley

    Diabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Screening patients is essential; physicians should address underlying risk factors to reduce the likelihood of developing...

    Chronic Low Back Pain in Adults: Evaluation and Management

    Donald Clinton Maharty, Shaun C. Hines, Regina Bray Brown

    Chronic low back pain is defined as lumbar pain persisting for 12 weeks or longer. Routine imaging is not recommended. Nonpharmacologic therapies, such as exercise and physical therapy, are first-line management. Physicians should consider prevention of chronic low back pain...

    Pancreatic Cancer: Rapid Evidence Review

    Carl Bryce, Merima Bucaj

    This article provides a summary and review of the best available patient-oriented evidence for pancreatic cancer.

    Hypertensive Disorders of Pregnancy

    Narges Farahi, Fareedat Oluyadi, Andrea B. Dotson

    Hypertensive disorders of pregnancy are a major contributor to maternal morbidity and mortality in the United States and include chronic hypertension, gestational hypertension, preeclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome, eclampsia...

    Editorials: Controversies in Family Medicine

    Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? Yes: Metformin Is Still the Best Choice

    Gregory Castelli, Stacy J. Bartlett

    Metformin is the most commonly prescribed glucose-lowering medication worldwide and the recommended initial pharmacologic option in major clinical guidelines, including those from the International Diabetes Federation and American College of Physicians.

    Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? No: Other Drugs Have Stronger Evidence of Benefit

    Henry C. Barry

    Clinicians were excited when research showed that metformin reduces mortality and decreases complications associated with type 2 diabetes. However, enthusiasm has been tempered by further research that has yet to support these claims.

    AFP Clinical Answers

    Pleural Effusion, Giardia, Adnexal Mass, Testosterone Replacement, Chronic Kidney Disease, Scalp Psoriasis

    Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.

    Medicine by the Numbers

    Remote Delivery of Psychological Therapies May Improve Chronic Pain

    D. Jason Frasca, Michael Lustig, Soquel Rey

    We chose a color recommendation of yellow (more data are needed) for this intervention in treating chronic pain.

    Cochrane for Clinicians

    Thiazide Diuretics vs. Other Antihypertensive Drug Classes

    Arindam Sarkar, Katelyn D. Sarkar

    There is no mortality benefit in using thiazide or thiazide-like diuretics compared with other first-line antihypertensive drug classes; however, these diuretics most likely reduce cardiovascular events and heart failure compared with calcium channel blockers.

    Direct Oral Anticoagulants vs. Conventional Anticoagulants for the Treatment of VTE

    Joseph R. Yancey, Corey J. Herman

    Direct oral anticoagulants are as effective as conventional anticoagulants at preventing recurrent deep venous thrombosis or pulmonary embolism and reducing all-cause mortality. Direct oral anticoagulants slightly decrease the likelihood of major bleeding compared with...

    U.S. Preventive Services Task Force

    Screening and Preventive Interventions for Oral Health in Adults

    The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of routine screening or preventive interventions performed by primary care clinicians for oral health conditions, including dental caries or periodontal-related disease,...

    Putting Prevention Into Practice

    Screening and Preventive Interventions for Oral Health in Children, Adolescents, and Adults

    Sheena Harris, Susan J. Ching, Radhika Agarwal, Elizabeth Lees

    This PPIP quiz is based on the recommendations of the USPSTF.

    Photo Quiz

    An Infant With Widespread Nodules and Papules

    Oliver J. Wisco, Kyra Diehl, Tracy Funk, Jamie P. Schlarbaum, Lisa M. Cohen

    A 15-month-old infant presented with yellowish papules and nodules scattered on his trunk, back, scalp, and eyelids.

    Palpable Purpura

    Richard W. Novotny, Lien N. Trinh, Amy J. Gowan, Matthew C. Lomeli

    A 57-year-old woman presented with a nonpruritic rash associated with paresthesia, myalgia, and worsening joint pain.

    Lown Right Care

    Avoiding Delays in Diagnosing Endometriosis

    Alan R. Roth, Andy Lazris, Patient perspective by Helen Haskell, John James

    A collaboration between AFP and the Lown Institute promotes a vision of delivering heath care that is based on the evidence, balanced in its approach, and focused on the patient.

    FPIN's Clinical Inquiries

    Does Melatonin Prevent Hospital-Acquired Delirium?

    Jacare Cardoza, Leah Foley, Yilin Zhang, Jon O. Neher, Sarah Safranek

    Melatonin should not be used to prevent hospital-acquired delirium because it does not reduce the incidence, duration, or complications of delirium, including increased length of stay or mortality.


    Fezolinetant (Veozah) for the Treatment of Menopause Symptoms

    Cortney Crespo, Deborah Erlich

    Fezolinetant is well tolerated; however, it is more expensive and less effective than hormone therapy or available nonhormonal treatments for the relief of vasomotor symptoms associated with menopause.

    Point-of-Care Guides

    ASCCP Management Guidelines for Abnormal Cervical Cancer Screening

    Kiana Espinosa

    How should abnormal test results be managed in patients who have had cervical cancer screening?

    Diagnostic Tests

    DermTech Pigmented Lesion Assay for the Detection of Melanoma

    Kiana Espinosa

    The PLA is an objective, noninvasive tool that decreases the need to biopsy melanocytic lesions in some skin regions. However, its accuracy requires improvement.

    Curbside Consultation

    What Physicians Need to Know About Over-the-Counter Hearing Aids

    Brian K. Unwin, Julia M. D'Amora, Corinne O'Shaughnessy

    Reports of perceived hearing loss should be taken seriously and explored with patients. Of American adults 75 years or older, 50% have perceived disabling hearing loss; fewer than one-third of patients 70 years and older who could benefit from hearing aids have ever used them.


    Wrong Blood Pressure Cuff Size Can Falsely Increase or Decrease Readings

    Allen F. Shaughnessy

    Cognitive Behavior Therapy Effective in Patients With Fatigue Associated With Long COVID

    Mark H. Ebell

    ACC/AHA Guideline for the Management of Patients With Chronic Coronary Disease

    Mark H. Ebell

    Amitriptyline as Second-Line Therapy Improves Symptoms in Adults With Irritable Bowel Syndrome

    Henry C. Barry

    Practice Guidelines

    Management of Acute Lower GI Bleeding: Guidelines From the American College of Gastroenterology

    Matthew K. Hawks

    The American College of Gastroenterology has published updated guidelines for the management of acute lower GI bleeding.


    All editors in a position to control content for this activity, AFP journal, are required to disclose any relevant financial relationships. View disclosures.

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