August 2025

Articles

Heart Failure With Reduced Ejection Fraction: Medical Management

Robert L. Gauer, Adam Rifaat, Ashley M. Foulkrod

Treatments shown to reduce morbidity and mortality risk in patients with heart failure with reduced ejection fraction include renin-angiotensin system inhibitors/neprilysin inhibitors, beta blockers, mineralocorticoid receptor antagonists, and sodium-glucose cotransporter-2…

Hyperthyroidism: Diagnosis and Treatment

Anne Mounsey, Ryan Paulus, Wesley Roten

Hyperthyroidism is an overproduction of thyroid hormone in the thyroid gland. Thyrotoxicosis, a thyroid hormone excess, can be caused by hyperthyroidism, thyroiditis, or exogenous administration. Graves disease can be diagnosed by thyroid eye disease or thyrotropin receptor…

Outpatient Care of the Premature Infant

Michael Bybel, Catherine A. Delaney, Katie Coble

In 2023, approximately 10% of all births in the United States were preterm (occurring at less than 37 weeks’ gestation). Various medical and neurodevelopmental morbidities are possible across the spectrum of prematurity, which may profoundly affect the newborn and family…

Seborrheic Dermatitis: Diagnosis and Treatment

Nicholas M. LeFevre, Kara Braudis, Lawrence S. Feigenbaum

Seborrheic dermatitis clinically presents as symmetric, poorly defined erythematous patches with yellow, oily scales and fine, superficial desquamation (flaking). It responds favorably to over-the-counter and prescription antifungal, keratolytic, and anti-inflammatory agents.

Provision of Quality Contraceptive Services: Updates From National Guidelines

David A. Klein, Chloe E. Forlini, Patsy Kremsreiter

In 2024, the Centers for Disease Control and Prevention and the US Department of Health and Human Services Office of Population Affairs updated national guidelines on provision of quality contraceptive services and sexual and reproductive health care.

Nonopioid Pharmacologic Management of Chronic Noncancer Pain

Randi Sokol, Ellie Grossman, Rebecca Bourgery

Management of chronic pain should be individualized and based on shared decision-making. General principles include assessing and documenting the pain; focusing on functional goals and quality of life; setting reasonable expectations; promoting self-management strategies…

Editorials: Practice Alert

Practice Alert: Meningococcal Vaccines

Doug Campos-Outcalt

This editorial discusses the use of meningococcal vaccines in adolescents and young adults at average risk of meningococcal infection.

Editorials

The PEER Team: Simplifying Evidence, Empowering Primary Care

Michael R. Kolber, Adrienne J. Lindblad, Christina Korownyk

Patients Experience Evidence Research (PEER) is a trailblazing team that bridges the gap between research and practice in primary care. PEER blends medical evidence, clinical expertise, and cutting-edge research in the delivery of trustworthy scholarly products and medical…

Cochrane for Clinicians

Compression Therapy for Preventing the Recurrence of Venous Leg Ulcers

David Gregory, John W. Epling

Compression stockings can reduce the recurrence of venous leg ulcers, based on limited evidence. Higher-grade compression is more effective, but patients are more likely to be noncompliant with therapy.

Water Fluoridation for Dental Caries Prevention

Dongsheng Jiang, Juan Qiu

Fluoridating water may result in a small reduction in tooth decay in children’s primary teeth, but its impact on permanent teeth remains unclear. Community water fluoridation may slightly decrease the proportion of children with “decayed, missing, or filled” primary and…

FPIN's Clinical Inquiries

Use of Delayed Pushing in Nulliparous Birthing Patients With an Epidural

Lee Dresang, Leslie Christensen

Clinicians should use shared decision-making with the pregnant patient to decide whether to delay pushing in the second stage of labor. Delayed pushing in the second stage among nulliparous pregnant patients with an epidural is associated with increased risks of postpartum…

Medicine by the Numbers

Oakland Score for Predicting Safe Discharge and Major Risks After Lower Gastrointestinal Bleeding

Samuel Lichtman Evans, Karen Xiao, Elias Youssef

We have assigned a color of yellow (unclear benefits) for using the Oakland score for predicting safe discharge and major risks after lower GI bleeding. The Oakland score could be used to predict risk for major bleeding, need for blood transfusion, and need for hemostasis…

Photo Quiz

Palpable Mass in a 12-year-old Girl With Abdominal Pain

Courtney Humphrey, Michael Scholl

A 12-year-old premenarchal girl presented with abdominal pain.

Difficulty Swallowing

Monica Kalra, Erinn Pemberton

A 35-year-old woman reported feeling pressure in her lower neck and chest.

U.S. Preventive Services Task Force

Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for iron deficiency and iron deficiency anemia in pregnant persons to prevent adverse maternal and infant health outcomes. The USPSTF concludes that the…

Diary of a Family Physician

Diary of a Family Physician

Ramona Sharma, Stephen Dudley

First-person accounts from the front lines of family medicine.

Putting Prevention Into Practice

Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy

Sheena Harris, Joseph Merfeld, Stephen Kane

This PPIP quiz is based on the recommendations of the USPSTF.

AFP Clinical Answers

FREE

Alzheimer Disease, de Quervain Tenosynovitis, Degenerative Meniscal Tears, Pet Therapy, Herpes Simplex Virus, Bone Stress Injuries

Key clinical questions and their evidence-based answers directly from the journal’s content, written by and for family physicians.

POEMs

Practice Guidelines

Resuscitation of Patients With Burns: Guidelines From the American Burn Association

Michelle Nelson

Providing intravenous fluids to prevent burn shock is challenging in the first 48 hours following an acute burn injury in adults with burns covering 20% or more of their total body surface area (TBSA). Intravascular fluid depletion from insufficient resuscitation can lead to…

Letters to the Editor

FREE

CPCs Should Be a Resource for Patients With Unintended Pregnancy

Kathleen Castellanos

Reply: Christina Valerio

FREE

Reconsidering the Harms of Delayed Prostate Cancer Screening

Kevin C. Kelleher

Reply: Kenneth W. Lin

FREE

Case Report: Acute Myocarditis Leading to Death in a Previously Healthy Adolescent Patient

Carl R. Pullen, Arturo Bravo Nuevo, Brian Heist

Letter to the Editor

CME Course Information

Evidence-based Medicine Toolkit

Strength of Recommendation Taxonomy

Advertising: Career Opportunities (PDF download)

Disclosures

All editors in a position to control content for this activity, AFP journal, are required to disclose any relevant financial relationships. View disclosures.

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