• AFP's Top 20 Articles By Year


    The following lists are the 20 most popular articles from each year according to page views on the website. The articles are listed in order of most views.

    2019

    Treatment of the Common Cold

    Katharine C. DeGeorge, Daniel J. Ring, and Sarah N. Dalrymple
    Acute upper respiratory tract infection, also called the common cold, is the most common acute illness in the United States. Informing patients about the self-limited nature of this illness can help manage expectations, limit antibiotic use, and avoid over-the-counter purchases that are unlikely to help. Treatments with proven effectiveness for cold symptoms in adults include over-the-counter analgesics, zinc, nasal decongestants with or without antihistamines, and intranasal ipratropium. The only safe and effective treatments for children are analgesics, acetylcysteine, honey, nasal saline irrigation, intranasal ipratropium, and menthol rub. September 1, 2019

    Type 2 Diabetes Therapies: A STEPS Approach

    Joshua Steinberg and Lyndsay Carlson
    Several recent large randomized controlled trials have significantly improved physicians’ knowledge about the impact of medications for type 2 diabetes mellitus on patient-oriented outcomes. A concise and organized way to evaluate pharmacotherapy options is to use the five patient-oriented STEPS criteria: safety, tolerability, effectiveness, price, and simplicity. The first-line treatment option, metformin, is safe and fairly well-tolerated, has excellent long-term effectiveness on patient-oriented outcomes, is moderately priced, and has a simple dosing regimen. However, most patients with type 2 diabetes require more than one medication. The STEPS approach can help choose subsequent medications if metformin does not provide adequate glycemic control. February 15, 2019

    Migraine Headache Prophylaxis

    Hien Ha and Annika Gonzalez
    Many patients with episodic migraine headaches would benefit from preventive therapy, which reduces frequency, severity, and distress from migraines; preventive therapy could improve quality of life and prevent chronic migraines. Indications for preventive therapy include four or more headaches a month, eight or more headache days a month, debilitating headaches, and medication-overuse headaches. Several first- and second-line medications are available for treatment; identifying and managing environmental, dietary, and behavioral triggers can also be useful. Relaxation training, thermal biofeedback, electromyographic feedback, and cognitive behavior therapy have good evidence as nonpharma­cologic ways to prevent episodic migraines. January 1, 2019

    Anticoagulation: Updated Guidelines for Outpatient Management

    Patricia Wigle, Brad Hein, and Christopher R. Bernheisel
    Vitamin K antagonists, unfractionated heparin, low-molecular-weight heparin, and direct oral anticoagulants are commonly used for the prevention and treatment of systemic embolism associated with atrial fibrillation, stroke, and venous thromboembolism. Low-molecular-weight heparin and select direct oral anticoagulants can be used for anticoagulation therapy initiation on an outpatient basis. Indications for anticoagulation therapy, direct oral anticoagulant therapy, and recommendations from guidelines are addressed in this article. October 1, 2019

    Patellofemoral Pain Syndrome

    David Y. Gaitonde, Alex Ericksen, and Rachel C. Robbins
    Patellofemoral pain syndrome, a common cause of knee pain in adolescents and adults younger than 60 years, can cause limitations in daily physical activity and ability to exercise if undiagnosed. The cardinal feature of patellofemoral pain syndrome is pain in or around the anterior knee that intensifies when the knee is flexed during weight-bearing activities. The diagnosis is clinical, and pain with squatting is the most sensitive physical examination finding. Treatment includes rest, a short course of nonsteroidal anti-inflammatory drugs, and physical therapy with strengthening exercises. January 15, 2019

    Plantar Fasciitis

    Thomas Trojian and Alicia K. Tucker
    Plantar fasciitis is common in runners but can also affect sedentary people. Risk factors include limited ankle dorsiflexion, increased body mass index, and standing for prolonged periods of time. Symptoms are stabbing, nonradiating pain first thing in the morning in the proximal medioplantar surface of the foot; the pain becomes worse at the end of the day. Treatment should start with stretching of the plantar fascia, ice massage, and nonsteroidal anti-inflammatory drugs. Many conservative treatments have not shown benefit over placebo. Recalcitrant plantar fasciitis can be treated with injections, extracorporeal shock wave therapy, or surgical procedures. June 15, 2019

    Acne Vulgaris: Diagnosis and Treatment

    Linda K. Ogé, Alan Broussard, and Marilyn D. Marshall
    Typical acne lesions involve the pilosebaceous follicles and the inter­related processes of sebum production, Cutibacterium acnes colonization, and inflammation. Treatment is based on severity and usually includes topical agents such as retinoids, benzoyl peroxide, and antibiotics. Oral antibiotics and isotretinoin may be used for severe, recalcitrant acne. Combination oral contraceptives and spironolactone are also used in some patients. Further study is needed to determine the effectiveness of complementary therapies and physical modalities such as laser therapy and light therapy. October 15, 2019

    Current Concepts in Concussion: Initial Evaluation and Management

    Keith A. Scorza and Wesley Cole
    Concussion results from trauma to the head; it affects individuals physically, cognitively, and emotionally/behaviorally and is a major health concern. Headache is the most common symptom. Spine and serious brain injuries should be ruled out before diagnosis. Symptom checklists, neuropsychological tests, balance tests, and sideline assessment tools are used for diagnosis and monitoring recovery. Athletes with suspected concussion should not return to play until medically cleared. Brief cognitive and physical rest is the preferred management. Individuals should gradually return to activities, but those with risk factors, such as more severe symptoms immediately following injury, may require longer recovery periods. April 1, 2019

    Urinary Incontinence in Women: Evaluation and Management

    Jocelyn S. Hu and Elyse Fiore Pierre
    Urinary incontinence (UI) is a common problem in women, resulting in economic burden and decreased quality of life. The Women’s Preventive Services Initiative is the only major organization that recommends annual screening for UI in all women. Initial evaluation should determine whether incontinence is transient or chronic, the subtype of the incontinence, and whether any findings warrant subspecialist referral. Pelvic floor strengthening and lifestyle modifications are first-line recommendations for all UI subtypes. No medications are approved by the U.S. Food and Drug Administration for treatment of stress incontinence; antimuscarinic medications may be prescribed for urge incontinence. Patients with refractory symptoms should be referred for more invasive management. September 15, 2019

    Hand-Foot-and-Mouth Disease: Rapid Evidence Review

    Aaron Saguil, Shawn F. Kane, Rebecca Lauters, and Michael G. Mercado
    Hand-foot-and-mouth disease is most commonly caused by enterovirus 71 and coxsackievirus A16. Clinical diagnosis is based on the presentation of a low-grade fever with a maculopapular or papulovesicular rash on the hands and soles of the feet, and by painful oral ulcerations. The largest incidence of the disease is within the first five years of life, and most cases occur in patients younger than 10 years. Handwashing, specifically after diaper changes and toileting, and before eating, helps stop the spread of the disease. October 1, 2019

    Abnormal Uterine Bleeding in Premenopausal Women

    Noah Wouk and Margaret Helton
    Abnormal uterine bleeding is a common symptom in reproductive-aged women. The acronym PALM-COEIN facilitates the classification of bleeding, with PALM referring to structural etiologies (polyp, adenomyosis, leiomyoma, malignancy and hyperplasia), and COEIN referring to nonstructural etiologies (coagulopathy, ovulatory dysfunction, endometrial, iatrogenic, not otherwise classified). Evaluation includes a detailed history and pelvic examination, as well as laboratory testing to rule out anemia and pregnancy. Endometrial sampling should be performed in patients 45 years and older, and in younger patients with a significant history of unopposed estrogen exposure. To avoid surgical risks and preserve fertility, medical management is the preferred initial approach for most hemodynamically stable patients. April 1, 2019

    Kidney Stones: Treatment and Prevention

    Leonardo Ferreira Fontenelle and Thiago Dias Sarti
    In patients with suspected kidney stones, the first priority is to rule out conditions requiring immediate referral to an emergency department, then to alleviate pain. The diagnostic workup consists of urinalysis, urine culture, and imaging to confirm the diagnosis and assess for conditions requiring active stone removal. Conservative management consists of pain control, medical expulsive therapy with an alpha blocker, and follow-up imaging to monitor stone position and assess for hydronephrosis. Asymptomatic kidney stones should be followed with serial imaging and should be removed if they become larger or if symptoms, urinary obstruction, or infection occurs. All patients with kidney stones should be screened for risk of stone recurrence. April 15, 2019

    Otitis Media: Rapid Evidence Review

    Heidi L. Gaddey, Matthew Thomas Wright, and Tracy N. Nelson
    Acute otitis media, the most common diagnosis in childhood acute sick visits, can cause ear pain, fever, irritability, otorrhea, anorexia, and sometimes vomiting and lethargy. Acute otitis media is diagnosed in children with moderate to severe bulging of the tympanic membrane or new-onset otorrhea not caused by acute otitis externa, and in children with mild bulging and recent-onset ear pain or intense erythema of the tympanic membrane. Treatment usually consists of pain management and antibiotics. However, observation with deferment of initial antibiotics is an option in some children without severe symptoms. Pneumococcal and influenza vaccines and exclusive breastfeeding until at least six months of age can reduce the risk of acute otitis media. September 15, 2019

    Gastroenteritis in Children

    Scott Hartman, Elizabeth Brown, Elizabeth Loomis, and Holly Ann Russell
    Acute gastroenteritis, defined as a diarrheal disease of rapid onset, with or without nausea, vomiting, fever, or abdominal pain, is not a major cause of death in the United States but leads to significant morbidity. Physical examination is the best way to assess hydration. Mild to moderate dehydration can be treated with oral rehydration therapy. Half-strength apple juice followed by preferred fluids may be used for mild dehydration, and an oral rehydration solution with or without an antiemetic should be used for moderate dehydration. Hospitalization and intravenous rehydration are recommended for children who do not respond to oral rehydration therapy plus an antiemetic and patients with severe dehydration. February 1, 2019

    Influenza: Diagnosis and Treatment

    David Y. Gaitonde, Faith C. Moore, and Mackenzie K. Morgan
    The hallmark of influenza infection is abrupt onset of fever, cough, chills or sweats, myalgias, and malaise. For most patients in the outpatient setting, the diagnosis is made clinically, and laboratory confirmation is not necessary. Laboratory testing may be useful in hospitalized patients with suspected influenza and in patients for whom a confirmed diagnosis will change treatment decisions. Rapid molecular assays are the preferred diagnostic tests. Treatment with one of four approved anti-influenza drugs may be considered if the patient presents within 48 hours of symptom onset. Annual influenza vaccination is recommended for all people six months and older who do not have contraindications. December 15, 2019

    Gas, Bloating, and Belching: Approach to Evaluation and Management

    John M. Wilkinson, Elizabeth W. Cozine, and Conor G. Loftus
    Gas, bloating, and belching are most often caused by functional gastrointestinal disorders. Psychological distress often makes the symptoms worse. Exhaustive testing is not necessary for diagnosis. Most patients are classified as having gastric or small bowel bloating, bloating with constipation, or belching disorders, with functional dyspepsia, irritable bowel syndrome, and chronic idiopathic constipation being the most common causes. Patients with symptoms of irritable bowel syndrome should be tested for celiac disease, and patients with chronic constipation should have a rectal examination to evaluate for dyssynergic defecation. March 1, 2019

    Acute Hand Infections

    Caitlyn M. Rerucha, John T. Ewing, Kathryn E. Oppenlander, and Wesley Charles Cowan
    Any trauma to the hand, particularly a penetrating trauma, may introduce damaging pathogens. Superficial infections occur in the skin and subcutaneous tissues, whereas deep infections can involve the tendon sheaths, adjacent anatomic compartments, deep fascial planes, bursae, joint spaces, and bones. Superficial hand infections are more common than deep infections and are typically managed with elevation, warm soaks, splinting in the position of function, analgesics, and empiric antibiotics when indicated. Clenched-fist bite wounds result from direct contact of the fist on incisor teeth and are associated with polymicrobial infections. Empiric antibiotics and prompt surgical consultation are indicated to reduce long-term morbidity. February 15, 2019

    Erythema Multiforme: Recognition and Management

    Kathryn P. Trayes, Gillian Love, and James S. Studdiford
    Erythema multiforme is an immune-mediated reaction that involves the skin and sometimes the mucosa. Erythema multiforme lesions can be isolated, recurrent, or persistent, and are classically described as target-like with three concentric segments: a dark center, surrounded by a lighter pink ring, both of which are surrounded by a red ring. Infections, especially herpes simplex virus and Mycoplasma pneumonia, and medications constitute most of the causes of erythema multiforme. Management of erythema multiforme depends on the underlying etiology and the disease severity. July 15, 2019

    Health Maintenance in School-Aged Children: Part I. History, Physical Examination, Screening, and Immunizations

    Margaret Riley, Leigh Morrison, and Anna McEvoy
    The goals of the health maintenance visit in school-aged children (five to 12 years) are promoting health, detecting disease, and counseling to prevent injury and future health problems. The visit should include a history (e.g., hospital care since the previous visit, living situation, lifestyle habits, school performance, social determinants of health); physical examination; and appropriate screening, such as depression, dyslipidemia, hypertension, hearing, and vision assessments. Immunizations should be given based on the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices immunization schedule. August 15, 2019

    Toilet Training: Common Questions and Answers

    Drew C. Baird, Michael Bybel, and Adam W. Kowalski
    Most U.S. children achieve the physiologic, cognitive, and emotional development necessary for toilet training by 18 to 30 months of age, although some children require more time. Markers of readiness for toilet training include being able to walk, don and remove clothing, and follow parental instruction; expressive language; awareness of a full bladder or rectum; and demonstrated dissatisfaction with a soiled diaper. Physicians should provide anticipatory guidance to parents beginning at about 18 to 24 months of age, noting the signs of toilet training readiness, and setting realistic expectations for parents. Complications of toilet training include stool toileting refusal, stool withholding, encopresis, hiding to defecate, and enuresis. These problems typically resolve with time. October 15, 2019

    2018

    Type 2 Diabetes Mellitus: Outpatient Insulin Management

    Amanda Howard-Thompson, Muneeza Khan, Morgan Jones, and Chritsa M. George
    In patients with type 2 diabetes mellitus, insulin may be used to augment therapy with oral glycemic medications or as insulin replacement therapy. Insulin regimens should be adjusted every three or four days until self-monitoring of blood glucose targets are reached. Goals should be individualized. January 1, 2018

    Acute Migraine Headache: Treatment Strategies

    Laura Mayans and Anne Walling
    Migraine is a chronic condition characterized by recurrent attacks. Acetaminophen, nonsteroidal anti-inflammatory drugs, triptans, antiemetics, ergot alkaloids, and combination analgesics have evidence supporting their effectiveness. Learn about the three treatment strategies recommended for migraine and when to consider prophylactic therapy. February 15, 2018

    Vitamin D Screening and Supplementation in Community-Dwelling Adults: Common Questions and Answers

    Michael L. LeFevre and Nicholas M. LeFevre
    Measuring vitamin D levels and prescribing oral vitamin D supplementation is common in clinical practice, although the health benefits have not been established. Clinical trials have not found vitamin D to be beneficial for chronic nonskeletal conditions, and screening and supplementation are not recommended in asymptomatic individuals. February 15, 2018

    Knee Pain in Adults and Adolescents: The Initial Evaluation

    Christopher W. Bunt, Christopher E. Jones, and Jennifer G. Chang
    Knee pain affects nearly 25% of adults. This article reviews the initial primary care office evaluation of knee pain and describes systematic approaches to evaluation. It also defines instances in which radiographic imaging, musculoskeletal ultrasound, magnetic resonance imaging, and laboratory tests should be performed. November 1, 2018

    Mechanical Low Back Pain

    Joshua Scott Will, David C. Bury, and John A. Miller
    Repetitive trauma and overuse are common causes of chronic mechanical low back pain. The history and physical examination can point toward a specific etiology, and imaging should generally be used only in the presence of red flags. Evidence-based therapies include nonsteroidal anti-inflammatory drugs, topiramate, and physical therapy. October 1, 2018

    Hemorrhoids: Diagnosis and Treatment Options

    Timothy Mott, Kelly Latimer, and Chad Edwards
    Treatment of hemorrhoids begins with conservative therapies, such as a high-fiber diet, increased water intake, warm water baths, fiber supplementation, stool softeners, and topical preparations. If these are unsuccessful, office-based and surgical procedures are warranted. Office-based procedures are generally more effective for lower-grade hemorrhoids. February 1, 2018

    Heel Pain: Diagnosis and Management

    Priscilla Tu
    The differential diagnosis of heel pain is extensive, but a mechanical etiology is the most common. Learn the most likely causes of heel pain based on the specific anatomic location affected. January 15, 2018

    Diets for Health: Goals and Guidelines

    Amy Locke, Jill Schneiderhan, and Suzanna M. Zick
    Patients and physicians often have difficulty staying abreast of diet trends, many of which focus primarily on weight loss rather than nutrition and health. Find out which dietary approaches have proven benefits for cardiovascular disease, cancer, type 2 diabetes mellitus, and obesity. June 1, 2018

    Well-Child Visits for Infants and Young Children

    Katherine Turner
    Well-child visits involve comprehensive assessment of a child. Complete history, head-to-toe examination, review of immunizations, and screening for postpartum depression in mothers of infants are performed. The physician answers questions and provides age-appropriate guidance. September 15, 2018

    Ear Pain: Diagnosing Common and Uncommon Causes

    John Scott Earwood, Tyler Sherrod Rogers, and Nicholas Alan Rathjen
    When patients present with otalgia, the first step is to determine whether the pain is originating from inside or outside the ear. Review the history and physical examination findings that can help identify the diagnosis, as well as the risk factors that may indicate a more serious condition. January 1, 2018

    Vaginitis: Diagnosis and Treatment

    Heather L. Paladine and Urmi A. Desai
    Review the diagnosis and treatment strategies for the three main causes of vaginitis: bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis. Treatment during pregnancy and treatment of recurrent episodes are also discussed. March 1, 2018

    The Adult Well-Male Examination

    Joel J. Heidelbaugh
    The goal of the adult well male examination is to promote optimal health and well-being, prevent premature morbidity and mortality from chronic diseases, and provide appropriate cancer screening and immunizations. This article summarizes evidence-based guidelines for counseling and screening in men. December 15, 2018

    Geriatric Assessment: An Office-Based Approach

    Paul E. Tatum III, Shaida Talebreza, and Jeanette S. Ross
    The goal of the geriatric assessment is to evaluate factors that influence patients’ overall well-being and to identify problems that impair quality of life. Typical domains to assess include functional status, fall risk, medications, nutrition, vision, hearing, cognition, mood, and toileting. Medicare’s Annual Wellness Visit provides an opportunity to address these elements in a single office visit. June 15, 2018

    Common Running Injuries: Evaluation and Management

    Michael J. Arnold and Aaron L. Moody
    Most running injuries are due to overuse and typically respond to conservative treatment. Learn which tests can help diagnose patellar tendinopathy, patellofemoral pain syndrome, iliotibial band syndrome, Achilles tendinopathy, plantar fasciopathy, and tibial and hamstring injuries, and the recommended treatments for each condition. April 15, 2018

    Rheumatologic Tests: A Primer for Family Physicians

    Yousaf Ali
    Patients with a suspected connective tissue disorder should undergo serologic testing to confirm the diagnosis and in some cases, to monitor disease activity and predict flares. However, many serologic tests are nonspecific, and further testing may be necessary. Physicians should order these tests only when patients have a high pretest probability of a specific connective tissue disorder. August 1, 2018

    Stable Coronary Artery Disease: Treatment

    Michael M. Braun, William A. Stevens, and Craig H. Barstow
    Treatment of stable coronary artery disease involves risk factor management, antiplatelet therapy, and antianginal medications. Treatment of comorbidities should be optimized to reduce cardiovascular risk. This article includes a management algorithm and a stepwise approach for antiplatelet therapy. March 15, 2018

    Acute Appendicitis: Efficient Diagnosis and Management

    Matthew J. Snyder, Marjorie Guthrie, and Stephen Cagle
    Appendicitis is one of the most common causes of acute abdominal pain in adults and children. Find out which clinical decision rules are most useful in specific patient populations, when to use ultrasonography vs. computed tomography or magnetic resonance imaging, and which patients may be safely treated with antibiotics only. July 1, 2018

    Caring for Transgender and Gender-Diverse Persons: What Clinicians Should Know

    David A. Klein, Scott L. Paradise, and Emily T. Goodwin
    Transgender persons often face substantial health care disparities and barriers to care. Find out how to establish a safe and welcoming environment for these patients, and get the information you need to decide whether to take an active role in their care by evaluating for gender dysphoria and managing hormone therapy, or an adjunctive role by monitoring well-being and providing referrals. December 1, 2018

    Top 20 Research Studies of 2017 for Primary Care Physicians

    Mark H. Ebell and Roland Grad
    The latest installment of the top 20 research studies for primary care physicians includes studies on cardiovascular disease and hypertension, infections, diabetes mellitus, musculoskeletal problems, and cancer screening, among other topics. The five highest-rated practice guidelines are also summarized. May 1, 2018

    Evaluation of Suspected Dementia

    Nathan Falk, Ariel Cole and T. Jason Meredith
    Patients with suspected dementia can be screened in the primary care office setting with a brief screening tool. A positive screening result warrants more in-depth screening tests. Evaluation for depression, laboratory studies for possible medical conditions that affect memory, and magnetic resonance imaging of the brain should be performed if cognitive impairment is confirmed. March 15, 2018

     

    2017

    Dizziness: Approach to Evaluation and Management

    Herbert L. Muncie, Susan M. Sirmans, and Ernest James
    Find out how to distinguish central from peripheral causes, and which patients need urgent evaluation and treatment. February 1, 2017

    Deep Venous Thrombosis and Pulmonary Embolism: Current Therapy

    Jason Wilbur and Brian Shain
    Anticoagulation is the mainstay of therapy for venous thromboembolism. Most patients can be treated in the outpatient setting with low-molecular-weight heparin and a vitamin K antagonist (warfarin) or direct-acting oral anticoagulants. March 1, 2017

    Chronic Obstructive Pulmonary Disease: Diagnosis and Management

    Shari Gentry and Barry Gentry
    Learn about the latest recommendations from the Global Initiative for Chronic Obstructive Lung Disease, the American College of Physicians, and the National Institute for Health and Care Excellence. April 1, 2017

    Severe Asymptomatic Hypertension: Evaluation and Treatment

    Robert Gauer
    Severely elevated blood pressure without symptoms of target organ injury can often be managed in the outpatient setting. A gradual lowering of blood pressure over several days to weeks is recommended over aggressive reduction. April 15, 2017

    Hyperlipidemia: Drugs for Cardiovascular Risk Reduction in Adults

    Allen R. Last, Jonathan D. Ference, and Elizabeth Rollmann Menzel
    Review recommendations from two major guidelines on lipid-lowering drugs for the primary and secondary prevention of atherosclerotic cardiovascular disease events. Statins are preferred, although nonstatins may be appropriate in specific cases. January 15, 2017

    Syncope: Evaluation and Differential Diagnosis

    Lloyd A. Runser, Robert Gauer, and Alex Houser
    Learn how to categorize patients as low- or high-risk, and how risk stratification affects management. March 1, 2017

    Laceration Repair: A Practical Approach

    Randall T. Forsch, Sahoko H. Little, and Christa Williams
    The goals of laceration repair are to achieve hemostasis and optimal cosmetic results without increasing the risk of infection. Learn the best techniques for wound preparation and repair, including suture and other closure options. May 15, 2017

    Insomnia: Pharmacologic Therapy

    Eric Matheson and Barry L. Hainer
    Get the latest evidence to help choose between benzodiazepines, z-drugs, melatonin agonists, tricyclic antidepressants, antihistamines, atypical antipsychotics, suvorexant, and antiepileptics. July 1, 2017

    Acute Coronary Syndrome: Current Treatment

    Timothy L. Switaj, Scott R. Christensen, and Dean M. Brewer
    Management of acute myocardial infarction begins with antiplatelet therapy and anticoagulation therapy, among other medications as appropriate. Learn which reperfusion strategies are recommended for patients with ST elevation myocardial infarction and non–ST elevation acute coronary syndrome. February 15, 2017

    Acute Coronary Syndrome: Diagnostic Evaluation

    Craig H. Barstow, Matthew S. Rice, and Jonathan D. McDivitt
    Although chest pain is common with myocardial infarction, there are many noncardiac causes of chest pain. A diagnosis may not be possible based on initial presentation alone. The initial assessment includes evaluation of risk factors and presenting signs and symptoms, rapid electrocardiography, and serum cardiac troponin measurements. February 1, 2017

    Mildly Elevated Liver Transaminase Levels: Causes and Evaluation

    Robert C. Oh, Thomas R. Hustead, Syed M. Ali, and Matthew W. Pantsari
    Mild, asymptomatic elevations in transaminase levels are common in primary care. Nonalcoholic fatty liver disease is the most common cause and is often benign and treated with lifestyle modification. Learn about this and other less common causes of transaminase elevations. December 1, 2017

    Probiotics for Gastrointestinal Conditions: A Summary of the Evidence

    Thad Wilkins and Jacqueline Sequoia
    Probiotics are useful for treating a variety of gastrointestinal conditions. Review the conditions with the best supporting evidence for probiotic use, as well which probiotic species are most appropriate. August 1, 2017

    Subclinical Hyperthyroidism: When to Consider Treatment

    Ines Donangelo and Se Young Suh
    Learn about new research on the association between subclinical hyperthyroidism and the risk of cardiovascular disease and bone fractures. June 1, 2017

    Heart Failure Due to Reduced Ejection Fraction: Medical Management

    William E. Chavey, Robert V. Hogikyan, R. Van Harrison, John M. Nicklas
    Multiple medication classes have demonstrated mortality benefit in heart failure. Recent data have shown benefit in two new classes—angiotensin blocker/neprilysin inhibitors and sinus node modulator. January 1, 2017

    Vitamin B12 Deficiency: Recognition and Management

    Robert C. Langan, Andrew J. Goodbred
    Find out which patients should be screened, and get the latest evidence on the optimal method of replacement in patients with vitamin B12 deficiency. September 15, 2017

    Pleuritic Chest Pain: Sorting Through the Differential Diagnosis

    Brian V. Reamy, Pamela M. Williams, and Michael Ryan Odom
    Once diagnoses requiring emergent attention are excluded, a virus is a likely causative agent to consider. Some patients must be reexamined with radiography after they receive treatment to ensure complete resolution of illness. September 1, 2017

    Evaluation of Jaundice in Adults

    Matthew V. Fargo, Scott P. Grogan, and Aaron Saguil
    Jaundice can indicate significant underlying disease. Review key components of the history, physical examination, laboratory evaluation, and imaging tests to determine the cause. February 1, 2017

    Secondary Hypertension: Discovering the Underlying Cause

    Lesley Charles, Jean Triscott, and Bonnie Dobbs
    Review common causes of secondary hypertension, including renovascular hypertension, renal disease, primary hyperaldosteronism, and obstructive sleep apnea. October 1, 2017

    End-of-Life Care: Managing Common Symptoms

    Ross H. Albert
    Review the most effective strategies for managing pain, dyspnea, delirium and agitation, nausea and vomiting, constipation, and oropharyngeal secretions in patients approaching the end of life. March 15, 2017

    Chronic Cough: Evaluation and Management

    Charlie Michaudet and John Malaty
    Learn which four conditions are the most likely cause, which imaging tests to order, and when to refer patients with refractory cough to a subspecialist. November 1, 2017